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Role of Ascorbic Acid Supplementation on Prevention of Olanzapine Induced Metabolic Side Effects in Schizophrenic Patients
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Schizophrenia is one of the most debilitating disorders with devastating effects on its victims and their families. Atypical antipsychotics (AAPs) because of their superior efficacy, reduced side effects,&better compliance, have rapidly become the mainstay of treatment. However, these AAPs have unique side effect profile like weight gain, hyperglycemia, and hyperlipidemia. Although preliminary data suggest benefit of vitamin C in improving the lipid and glucose dysregulation, whether vitamin C as an antioxidant has any effect on improving drug induced metabolic derangements has not been clarified yet. Therefore, this prospective clinical trial has been carried out to determine the impact of vitamin C as an antioxidant in modifying these parameters in schizophrenic patients. Among 30 newly diagnosed DSM-IV patients of schizophrenia enrolled, mean body weight, BMI, blood sugar, and lipid profile were significantly increased from baseline to 6 and 12 weeks after treatment with olanzapine(p <0.001). However, there were no statistically significant differences in these parameters between patients who received only olanzapine and those who received both olanzapine and vitamin C. Thus, vitamin C as an antioxidant does not modify the metabolic side effect profile of olanzapine.
Keywords
Schizophrenia, Olanzapine, Vitamin C, Blood Sugar, Lipid Profile
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