Indian Journal of Public Health Research & Development

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Fetal Hemoglobin & Liver Dysfunction in Sickle Cell Crisis


Affiliations
1 Department of Pediatrics, Pt JNM Medical College, Raipur, CG, India
2 Department of Biochemistry, Pt JNM Medical College, Raipur, CG, India
3 Department of Biochemistry, Saraswati Institute of Medical College, Hapur, UP, India
     

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Fetal hemoglobin is one of the major factors that alters the clinical course of disease. A study of 45 patients of sickle cell crisis was carried out in Department of Biochemistry&Department of Pediatrics, Pt JNM Medical College, Raipur, Chhattisgarh between June 2007 to July 2009. All patients had homozygous sickle cell anemia admitted in our institutional hospital for sickle cell crisis. Patients were diagnosed by cellulose acetate electrophoresis and adult, fetal and sickle hemoglobin was quantitated by cation exchange HPLC (Biorad Variant hemoglobin testing system). The patients were divided into three groups based on the Hb F concentration in whole blood. Group I, II and III had 20 percent HbF respectively. HbF is higher in lesser age group but it was not statistically significant. The average Sickle cell crisis per year and recurrent events were 2.7, 3.2 and 1.4 in group-I, group-II and group-III respectively. So in group-III the crisis/year was less than compared to other two groups. The average number of blood transfusions in groups I, II&III till the study period was 14, 7.1 and 3.1 respectively. So there was a downward trend of no. of B.T with increasing level of HbF. There was significant drop in the requirement of B.T , reccurence of sickle cell crisis in the patients above HbF level of 20%. The mean size in centimeters of spleen was lower with increasing HbF level. but there was no significant difference in liver size. SGOT&SGPT was in normal reference range in patients with HbF level > 20% whereas it was abnormal in patients with HbF levels < 20%.. There was no significant difference in hematological parameters like Hb, MCV, HCT, RBC, MCH&MCHC between any of the groups. However platelet count was elevated with HbF levels < 20% and in normal range with HbF levels > 20%.
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  • Fetal Hemoglobin & Liver Dysfunction in Sickle Cell Crisis

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Authors

Sumanta Panigrahi
Department of Pediatrics, Pt JNM Medical College, Raipur, CG, India
Praveen Sablania
Department of Biochemistry, Pt JNM Medical College, Raipur, CG, India
P. K. Khodiar
Department of Biochemistry, Pt JNM Medical College, Raipur, CG, India
J. R. Keshari
Department of Biochemistry, Saraswati Institute of Medical College, Hapur, UP, India
Pradeep Kumar Patra
Department of Biochemistry, Pt JNM Medical College, Raipur, CG, India

Abstract


Fetal hemoglobin is one of the major factors that alters the clinical course of disease. A study of 45 patients of sickle cell crisis was carried out in Department of Biochemistry&Department of Pediatrics, Pt JNM Medical College, Raipur, Chhattisgarh between June 2007 to July 2009. All patients had homozygous sickle cell anemia admitted in our institutional hospital for sickle cell crisis. Patients were diagnosed by cellulose acetate electrophoresis and adult, fetal and sickle hemoglobin was quantitated by cation exchange HPLC (Biorad Variant hemoglobin testing system). The patients were divided into three groups based on the Hb F concentration in whole blood. Group I, II and III had 20 percent HbF respectively. HbF is higher in lesser age group but it was not statistically significant. The average Sickle cell crisis per year and recurrent events were 2.7, 3.2 and 1.4 in group-I, group-II and group-III respectively. So in group-III the crisis/year was less than compared to other two groups. The average number of blood transfusions in groups I, II&III till the study period was 14, 7.1 and 3.1 respectively. So there was a downward trend of no. of B.T with increasing level of HbF. There was significant drop in the requirement of B.T , reccurence of sickle cell crisis in the patients above HbF level of 20%. The mean size in centimeters of spleen was lower with increasing HbF level. but there was no significant difference in liver size. SGOT&SGPT was in normal reference range in patients with HbF level > 20% whereas it was abnormal in patients with HbF levels < 20%.. There was no significant difference in hematological parameters like Hb, MCV, HCT, RBC, MCH&MCHC between any of the groups. However platelet count was elevated with HbF levels < 20% and in normal range with HbF levels > 20%.

References