Role of Anti-cardiolipin Antibodies in Recurrent Spontaneous Abortions

Introduction: Anti-cardiolipin antibodies are autoantibodies which may be associated with unexplained recurrent abortions.

Aims&Objectives: To evaluate the role of anti-cardiolipin antibodies in unexplained, recurrent abortions.

Materials&Method: A cohort of 28 females with recurrent spontaneous abortions were studied for anti-cardiolipin antibodies by ELISA. 20 normal fertile age matched females served as controls.

Result: 25% cohorts were positive for anti-cardiolipin antibodies. They also had increased frequency of the antibody (35%) as compared to primary aborters (12.5%). All healthy controls were negative. All positive cases were either moderately or weakly positive for the antibody by ELISA.

Conclusion: Anti-cardiolipin antibodies may be associated with spontaneous recurrent abortion. It should be tested in all cases of recurrent miscarriages.