Indian Journal of Physiotherapy & Occupational Therapy-An International Journal

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Effect of Aerobic Exercises on Serum IgE and Pulmonary Functions in Children with Bronchial Asthma


Affiliations
1 Department of Physical Therapy for Cardiovascular/Respiratory Disorders and Geriatrics, Faculty of Physical Therapy, Cairo University, Egypt
2 2Department of Physical Therapy for Growth and Development Disorders in Children and its Surgery, Faculty of Physical Therapy, Cairo University, Egypt
     

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Purpose: The aims of present study was to evaluate the effect of aerobic exercise training on serum IgE and pulmonary functions in asthma children before and after exercise program.

Subjects: 60 children with asthma participated in this study and divided randomly to exercise and control groups.

Procedure: Fasting serum IgE and some markers indicative of respiratory functions (FEV1, FVC, and FEV1/FVC) were measured before and after the study in both groups. Statistical analysis was performed with the SPSS software version 15.0 using an independent paired t-test.

Results: Compared to pre-training, serum IgE decreased significantly and pulmonary function markers increased significantly (≥0.05) after exercise program. All variables remained without change in control group (≥0.05).

Conclusion: Aerobic exercise program was associated with a significant decrease in serum level of IgE and improvement of pulmonary functions in asthmatic children.


Keywords

Immunoglobulin E(IgE), Pulmonary Functions, Asthma, Aerobic Exercise
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  • Sly RM. Allergic disorders. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson textbook of pediatrics, 16th edn. Philadelphia: WB Saunders Co.; 2000, pp. 664 -680.

  • Van Veldhoven NH, Vermeer A, Bogaard JM, Hessels MG, Wijnroks L, et al. Children with asthma and physical exrcise: effects of an exercise programme. Clin Rehabil 2001; 15: 360 -370.

  • Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M. Measuring quality of life in children with asthma. Qual Life Res 1996; 5: 35 -46.

  • Juniper EF. How important is quality of life in pediatric asthma? Pediatr Pulmonol 1997; (suppl 15): 17 -21.

  • Feleszko W, Jaworska J, Hamelmann E (2006). Toll-like receptors: novel targets in allergic airway disease (probiotics, friends and relatives). European Journal of Pharmacology 533(1-3): 308–318.

  • Bryce PJ, Mathias CB, Harrison KL, Watanabe T, Geha RS, Oettgen HC (2006). The H1 histamine receptor regulates allergic lung responses. Journal of Clinical Investigation 116(6): 1624–1632.

  • Burrows B, Martinez FD, Halonen M, Barbee RA, and Cline MG. Association of asthma with serum IgE levels and skin test reactivity to allergens. NEJM 320:270-277, 1989.

  • Mayr SI, Zuberi RI, Liu FT (2003). Role of immunoglobulin E and mast cells in murine models of asthma. Braz J Med Biol Res 36(7): 821-827.

  • MacGlashan Jr D, Lichtenstein LM, McKenzie- White J (1999). Upregulation of FcepsilonRI on human basophils by IgE antibody is mediated by interaction of IgE with FcepsilonRI. Journal of Allergy and Clinical Immunology 104(2): 492–8.

  • Holt PG, Macaubas C, Stumbles PA, Sly PD (1999). The role of allergy in the development of asthma. Nature 402 (6760 Suppl): 12–7.

  • Kay AB (2001). Allergy and allergic diseases. Second of two parts. New England Journal of Medicine 344(2): 109–13.

  • Powe DG, Jagger C, Kleinjan A, Carney AS, Jenkins D, Jones NS (2003). ‘Entopy’: localized mucosal allergic disease in the absence of systemic responses for atopy. Clinical & Experimental Allergy 33(10): 1374–1379.

  • Ying S, Humbert M, Meng Q (2001). Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma. Journal of Allergy and Clinical Immunology 107(4): 686–92.

  • Czy|ewska-BuczyDska A., Lewandowicz- UszyDska A., Jankowski A. IgA, an essential part of the immune system: selected issues. Post. Hig. Med. Dosw. 2007;61:38-47.

  • Gergen PJ, Arbes SJ Jr, Calatroni A, Mitchell HE, Zeldin DC (2009). Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005-2006. Journal of Allergy and Clinical Immunology 124(3): 447-53.

  • Heidenfelder B, Johnson M, Hudgens E, Inmon J, Hamilton RG, Neas L (2010). Increased plasma reactive oxidant levels and their relationship to blood cells, total IgE, and allergen-specific IgE levels in asthmatic children. Journal of Asthma 47(1): 106-11.

  • Thomas SS, Chhabra SK (2003). A study on the serum levels of interleukin-1beta in bronchial asthma. Journal of the Indian Medical association 101(5): 282- 286.

  • Sears MR, Burrows B, Flannery EM, Herbison GP, Hewitt CJ, and Holdaway MD (1991). Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. New England Journal of Medicine 325(15): 1067-1071.

  • Georas SN, Guo J, De Fanis U, Casolaro V. 2005. T–helper cell type-2 regulation in allergic disease. Eur Respir 26, 1119–1137.

  • Ishizaka T, Ishizaka K. 1984. Activation of mast cells for mediator release through IgE receptors. Prog Allergy 34(2), 188-235.

  • Gergen PJ, Arbes SJ Jr, Calatroni A, Mitchell HE, Zeldin DC. 2006. Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol 124(3), 447-53.

  • Rotsides DZ, Goldstein IF, Canfield SM, Perzanowski M, Mellins RB, Hoepner L et al. 2009. Asthma, allergy, and IgE levels in NYC head start children. Respir Med [Epub ahead of print].

  • Satwani H, Rehman A, Ashraf S, Hassan A. 2009. Is serum total IgE levels a good predictor of allergies in children?. J Pak Med Assoc 59(10), 698-702.

  • Jeurissen A, Bossuyt X, Ceuppens JL, Hespel P. The effects of physical exercise on the immune system. Ned Tijdschr Geneeskd 2003;147:1347-51.

  • Ram FS, Robinson RM, Black PN. Effects of physical training in asthma: a systematic review. Br J Sports Med 2000; 34: 162 -167.

  • Ulger Z, Demir E, Tanaç R, Gök_en D, Gülen F, Darcan S, et al. The effect of childhood obesity on respiratory function tests and airway hyperresponsiveness. Turk J Pediatr 2006; 48 (1): 43- 50.

  • Gerrard JW. The biological importance of IgE.Immunol. Allergy Pract 25:381-84, 1984.

  • Lebowitz MD, Barbee R, and Burrows B. Family concordance of IgE, atopy, and disease. J Allergy Clin Immunol 74:259-264, 1984.

  • Suzuki K., Nakaji S., Yamada M., Totsuka M., Sato K., Sugawara K. Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc. Immunol. Rev. 2002;8:6-48

  • Field CJ,Gougeon R,Marliss E B. Circulating mononuclear cell numbers and function during intense exercise and recovery.J Appl Physiol 1991;71:1089-97.

  • Nieman D.C. Does exercise alter immune function and respiratory infections? President’s Council on Physical Fitness and Sports 2001;3: 1-8.

  • Neder JA, Nery LE, Silva AC, Cabral ALB, Fernandes ALG. Short term effects of aerobic training in the clinical management of moderate to severe asthma in children. Thorax 1999; 54: 202 -206.

  • Van Veldhoven NH, Vermeer A, Bogaard JM, Hessels MG, Wijnroks L, et al. Children with asthma and physical exrcise: effects of an exercise programme. Clin Rehabil 2001; 15: 360 -370.


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  • Effect of Aerobic Exercises on Serum IgE and Pulmonary Functions in Children with Bronchial Asthma

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Authors

Aisha A. Hagag
Department of Physical Therapy for Cardiovascular/Respiratory Disorders and Geriatrics, Faculty of Physical Therapy, Cairo University, Egypt
Naglaa A. Zaky
2Department of Physical Therapy for Growth and Development Disorders in Children and its Surgery, Faculty of Physical Therapy, Cairo University, Egypt

Abstract


Purpose: The aims of present study was to evaluate the effect of aerobic exercise training on serum IgE and pulmonary functions in asthma children before and after exercise program.

Subjects: 60 children with asthma participated in this study and divided randomly to exercise and control groups.

Procedure: Fasting serum IgE and some markers indicative of respiratory functions (FEV1, FVC, and FEV1/FVC) were measured before and after the study in both groups. Statistical analysis was performed with the SPSS software version 15.0 using an independent paired t-test.

Results: Compared to pre-training, serum IgE decreased significantly and pulmonary function markers increased significantly (≥0.05) after exercise program. All variables remained without change in control group (≥0.05).

Conclusion: Aerobic exercise program was associated with a significant decrease in serum level of IgE and improvement of pulmonary functions in asthmatic children.


Keywords


Immunoglobulin E(IgE), Pulmonary Functions, Asthma, Aerobic Exercise

References