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K. S. Deshmukh ¹, N. Nath ¹, M. C. Nath ¹

Affiliations
1 University Department of Biochemistry, Nagpur, IN

Abstract

Disturbances in carbohydrate metabolism caused by feeding high fat diet in animals are well known. Whitney and Roberts, and Samuel et al reported that rats maintained on a high fat diet generally have higher blood sugar levels than those on a high carbohydrate diet. Increased fasting glucose levels in men placed on a high fat diet have also been reported. Kowale et al have evidenced more deleterious effects on carbohydrate metabolism by feeding high saturated fat than high unsaturated fat to animals.

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B. N. Kowale ¹, D. M. Brahmankar ¹, N. Nath ¹, M. C. Nath ¹

Affiliations
1 Department of Biochemistry, Nagpur, IN

Abstract

Whitney and Roberts, Samuels et al and others have reported that rats on a high fat diet generally have a higher blood sugar than rats on a high carbohydrate diet. The results of various workers indicated increased fasting glucose levels in men placed on a high fat diet. It has been shown that adaptation to fat feeding induced a slower rate of disappearance of blood sugar and a relatively low sensitivity to insulin. In vitro studies on isolated rat diaphragms from fat fed animals also showed the decreased glucose uptake coupled with an increased pyruvate and lactate formation.

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