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Badami, S.
- Evaluation of Tyrosinase Inhibitory Activity of some Indian Spices
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Journal of Natural Remedies, Vol 1, No 2 (2001), Pagination: 125-129Abstract
Objective: Evaluation of tyrosinase inhibitory activity of spices. Materials and methods: Ten different spices considered as usual commodity in Indian food habits was screened for their inhibitory activity against tyrosinase. The mushroom tyrosinase inhibitory activity was determined by dopachrome method using L-DOPA as the substrate. Results: Amongst the spices tested four spices viz. Turmeric (Curcuma longa ), cumin (Cuminum cyminum), black pepper (Piper nigrum), pipal (Ficus religiosa) showed the specific inhibitory activity against tryrosinase above 50% and out of them turmeric showed maximum inhibition which can be further explored for the characterization of the phytoconstituents. Other spices showed potential inhibition of tyrosinase activity. Conclusion: This finding could lead to the design and discovery of new tyrosinase inhibitors from Indian spices.Keywords
Tyrosinase Inhibitor, Alcohol Extract, Piper Nigrum, Ficus Religiosa, Myristica Fragrance, Nigella Sativa, Cinnamomum Tamala, Murraya Koenigii, Coriandrum Sativum, Cuminum Cyminum, Carum Carvi, Curcuma Longa- Androgenic Activity of the Total Alkaloid Fraction of Alangium salviifolium (Linn.F)
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PDF Views:566
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Journal of Natural Remedies, Vol 2, No 1 (2002), Pagination: 66-70Abstract
Objective: To perform the androgenic and anti-androgenic activity of the total alkaloid fraction of Alangium salviifolium (Family: Alangiaceae). Materials and methods: The total alkaloid fraction of the methanolic extract of stem bark of Alangium salviifolium was used for the experiment. Immature male albino rats received orally a dose of 10 mg and 20 mg/kg body weight of the fraction for 7 days. The weight of the reproductive organs of the treated rats was measured on the eighth day of the treatment and histometric measurements were carried out. Results: A significant increase in the weight of testis, seminal vesicles, ventral prostate and epididymis was observed in the treated rats. Conclusion: The results suggest the androgenic behaviour of the total alkaloid fraction.Keywords
Alangium salviifolium, Total Alkaloid Fraction, Androgenic Activity- Antiepileptic and Antipsychotic Effects of Ipomoea Reniformis (convolvulaceae) in Experimental Animals
Abstract Views :272 |
PDF Views:155
Authors
K. K. Chitra
1,
S. Babitha
1,
Sharanbasappa Durg
2,
B. S. Thippeswamy
1,
V. P. Veerapur
1,
S. Badami
1
Affiliations
1 Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur-572102, Karnataka, IN
2 Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur-572102, Karnataka Rajiv Gandhi University of Health Sciences, Bangalore-560041, Karnataka, IN
1 Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur-572102, Karnataka, IN
2 Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur-572102, Karnataka Rajiv Gandhi University of Health Sciences, Bangalore-560041, Karnataka, IN
Source
Journal of Natural Remedies, Vol 14, No 2 (2014), Pagination: 153-163Abstract
Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.- ICH Guidelines with Special Emphasis on Good Clinical Practice Guidelines (GCP)
Abstract Views :191 |
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Authors
Affiliations
1 Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur, Karnataka, IN
1 Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 1 (2010), Pagination: 27-32Abstract
Good Clinical Practice (GCP) is an international ethical and scientific quality standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical trials. It also serves to protect the rights, integrity and confidentiality of trial subjects. It is very important to understand the background of the formation of the ICH-GCP guidelines as this, in itself, explains the reasons and the need for doing so. In this paper, we address the historical background and the events that led up to the formation of these guidelines. Today, the ICH-GCP guidelines are used in clinical trials throughout the globe with the main aim of protecting and preserving human rights.Keywords
ICH, Good Clinical Practices Guidelines, Quality, Safety, Efficacy and Multidisciplinary.References
- Guidelines for good clinical practice (GCP) for trials on pharmaceutical products. Annex 3 of The Use of Essential Drugs Sixth report of the WHO, Expert Committee. Geneva. World Health Organization, 1995: 97-137.
- ASCO outlines minimum standards and exemplary attributes for research sites: Previews tools to be provided. J Oncol Pract 4:185-187.
- Singh S. International Conference on Harmonisation an update. The eastern Pharmacist. 1998:61:42-43.
- Artiges A, Sheinen E, Potter C, Tanimoto T, editors. Pharmacopoeial Harmonisation. Proceedings of the 6th International Conference on Harmonisation. 2003, Nov 12-15; Osaka, Japan.
- Yetter R, editor. Partnership in Harmonisation. Proceedings of the 6th International Conference on Harmonisation. 2003, Nov 12-15; Osaka, Japan.
- Amitava Roy, A Ghosh, the sixth international conference on hormonisation (ICH6)-A Promising Future in Global Pharmaceutical Industry, Research J.Pharm.and Tech. I (3): July-Sept.2008 pg no.161-165.
- S.D. Seth, Madhu khanna, Hand Book of Good Clinical Practice (GCP): Guidance for implementation, Indian J Med Res 125, May 2007, pp 701-704.
- Council for International Organizations of Medical Sciences. International Ethical Guidelines for Biomedical Research Involving Human Subjects. Geneva, CIOMS, 1993, Annex 1.
- Christley HM. (1998) Conducting Clinical Trials in South Africa. Applied Clinical Trials. September 7(9) 56-59.
- International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. (1996) ICH Tripartite Guideline. Guideline for Good Clinical Practice. Recommended for Adoption at Step 4 of the ICH Process on 1 May 1996 by the ICH Steering Committee.
- Malaysian Guidelines for Good Clinical Practice. 2nd edition. Ministry of Health Malaysia, 2004.
- European Medicines Agency. ICH Harmonised Tripartite Guideline E6: Note for Guidance on Good Clinical Practice (PMP/ICH/135/95). London: European Medicines Agency, 2002.
- A Vijayananthan, O Nawawi, The importance of Good Clinical Practice guidelines and its role in clinical trials, Biomed Imaging Interv J 2008; 4(1):e5, pg no.1-4.
- The World Medical Association. Declaration of Helsinki [Web Page]. 2004; Available at http://www.wma.net/e/policy/b3.htm.
- Microwave Assisted Isolation of Dye from Heartwood of Artocarpous heterophyllus Lam
Abstract Views :140 |
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Authors
Affiliations
1 Dept. of Pharmaceutical Chemistry, Karpagam Collage of Pharmacy, Otthakalmandapam, Coimbatore-600032, IN
2 Sree Siddaganga Collage of Pharmacy, Tumkur – 572 102, Karnataka, IN
3 Karpagam College of Pharmacy, Othakalmandapam, Coimbatore – 640032, IN
1 Dept. of Pharmaceutical Chemistry, Karpagam Collage of Pharmacy, Otthakalmandapam, Coimbatore-600032, IN
2 Sree Siddaganga Collage of Pharmacy, Tumkur – 572 102, Karnataka, IN
3 Karpagam College of Pharmacy, Othakalmandapam, Coimbatore – 640032, IN