Indian Journal of Science and Technology

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Association of rs1800790 in FGB and Endometrium in Iranian Women


Affiliations
1 Islamic Azad University, Tehran Medical Sciences Branch,Tehran
2 Molecular Genetics, Islamic Azad University, Tehran Medical Sciences Branch,Tehran, Iran
3 Molecular Genetics,The Cellular and Molecular Endocrine, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
 

Background/Objectives: Endometriosis is a disease with the growth of endometrium-like tissue in aberrant locations outside of the uterine. Variants of a number of genes have been associated to endometriosis; however, the contributions of these genetic variants in different ethnic groups are not similar. Methods/Statistical Analysis: Our study is Association of rs1800790 in FGB and endometrium in Iranian women. The case-control study included 100 affected patients and 100 controls. The genetic variants on FGB gene was genotyped using Tetra Amplification Refractory Mutation System-Polymerase Chain Reaction (Tetra-ARMS-PCR). Findings: Association of risk allele with endometriosis was examined using SPSS software. Results showed that FGB gene polymorphism genotype frequencies were compared in the patients and control. Frequency of AA, AG and GG genotypes of the gene polymorphismfibrinogen beta polypeptide chain were 28, 48 and 24% in patients respectively, and 66, 31and 3% in control group respectively. Results showed that relation between patients and control group is significant (P = 4.619e-11). Applications/Improvements: This study showed that there was meaningful relationship between FGB gene polymorphism and increased risk of endometriosis in women studied

Keywords

Endometriosis, FGB Gene, rs1800790, Women
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  • Association of rs1800790 in FGB and Endometrium in Iranian Women

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Authors

P. Zohre Omidi
Islamic Azad University, Tehran Medical Sciences Branch,Tehran
Mehrdad Hashemi
Molecular Genetics, Islamic Azad University, Tehran Medical Sciences Branch,Tehran, Iran
Ahmad Ebrahimi
Molecular Genetics,The Cellular and Molecular Endocrine, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract


Background/Objectives: Endometriosis is a disease with the growth of endometrium-like tissue in aberrant locations outside of the uterine. Variants of a number of genes have been associated to endometriosis; however, the contributions of these genetic variants in different ethnic groups are not similar. Methods/Statistical Analysis: Our study is Association of rs1800790 in FGB and endometrium in Iranian women. The case-control study included 100 affected patients and 100 controls. The genetic variants on FGB gene was genotyped using Tetra Amplification Refractory Mutation System-Polymerase Chain Reaction (Tetra-ARMS-PCR). Findings: Association of risk allele with endometriosis was examined using SPSS software. Results showed that FGB gene polymorphism genotype frequencies were compared in the patients and control. Frequency of AA, AG and GG genotypes of the gene polymorphismfibrinogen beta polypeptide chain were 28, 48 and 24% in patients respectively, and 66, 31and 3% in control group respectively. Results showed that relation between patients and control group is significant (P = 4.619e-11). Applications/Improvements: This study showed that there was meaningful relationship between FGB gene polymorphism and increased risk of endometriosis in women studied

Keywords


Endometriosis, FGB Gene, rs1800790, Women



DOI: https://doi.org/10.17485/ijst%2F2016%2Fv9i7%2F130854