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Effect of Doxorubicin on the Biochemical Activities of the Male Reproductive System of White Mice- Mus musculus


Affiliations
1 Department of Advanced Zoology & Biotechnology, Quaid-e-Millat Govt. College (W), Chennai-600 002, India
 

Doxorubicin is one of the chemotherapeutic agents in treating cancer. The present study was undertaken to investigate whether doxorubicin had any adverse effect when administered at the recommended dose. For this purpose, the effect of Doxorubicin on LDH, glucokinase, alkaline phosphatase, acid phosphatase and sialic acid at the recommended therapeutic dosage were studied. Doxorubicin treatment resulted in decreased protein, glycogen and alkaline phosphatase level and increase in glucokinase, LDH, ADP and sialic acid. When sufficient withdrawal time was given, most of these changes reverted to normal. From the outcome of this study it may be assumed that it is safe to administer doxorubicin at the recommended dosage (0.5-1 mg / kg body weight) as the effects are temporary and reversible.

Keywords

Doxorubicin, Glycogen, Lactate Dehydrogenase, Acid Phosphatase, Alkaline Phosphatase
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  • Effect of Doxorubicin on the Biochemical Activities of the Male Reproductive System of White Mice- Mus musculus

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Authors

Thiagarajan Sridevi
Department of Advanced Zoology & Biotechnology, Quaid-e-Millat Govt. College (W), Chennai-600 002, India

Abstract


Doxorubicin is one of the chemotherapeutic agents in treating cancer. The present study was undertaken to investigate whether doxorubicin had any adverse effect when administered at the recommended dose. For this purpose, the effect of Doxorubicin on LDH, glucokinase, alkaline phosphatase, acid phosphatase and sialic acid at the recommended therapeutic dosage were studied. Doxorubicin treatment resulted in decreased protein, glycogen and alkaline phosphatase level and increase in glucokinase, LDH, ADP and sialic acid. When sufficient withdrawal time was given, most of these changes reverted to normal. From the outcome of this study it may be assumed that it is safe to administer doxorubicin at the recommended dosage (0.5-1 mg / kg body weight) as the effects are temporary and reversible.

Keywords


Doxorubicin, Glycogen, Lactate Dehydrogenase, Acid Phosphatase, Alkaline Phosphatase

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DOI: https://doi.org/10.17485/ijst%2F2011%2Fv4i12%2F30317