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Effects of some Anti-histamine on Erythrocyte Aspartate Amino Transferase and Alanine Amino Transferase Activities in Wistar Albino Rats


Affiliations
1 Department of Biochemistry, Madonna University Elele Campus, Nigeria
2 Department of Biochemistry, University of Port Harcourt Choba, Nigeria
3 Department of Biochemistry, Anambra State University Uli, Nigeria
4 Department of Prosthesis and Orthopedic Technology, School of Health Technology Federal University of Technology, Owerri, Nigeria
 

The present study was conducted on the rat population of animal house in Madonna University, Elele Campus, Nigeria to evaluate the status of some biochemical parameters of rats administered with varied concentrations of chlorpheniramine maleate (piriton), cyproheptadine hydrochloride (cypron), and clemastine fumarate (tavagyl). Blood samples and liver organ were collected from 51 male and female albino rats, 48 were given different concentrations of each of the antihistamine drugs for 30 days, while 3 rats were used as control. Alanine amino transferase (ALT) activity and Aspartate amino transferase (AST) were lower in the control group compare to the groups administered with piriton, Cypron, and Tavagyl at 0.04mg/ml, 0.02mg/ml, 0.01mg/ml, and 0.005mg/ml. From the above results it is concluded that piriton, cypron, and Tavagyl increased the activities of AST and ALT enzymes.

Keywords

Alanine Amino Transferase, Aspartate Amino Transferase, Piriton, Cypron, and Tavagyl, Rat
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  • Effects of some Anti-histamine on Erythrocyte Aspartate Amino Transferase and Alanine Amino Transferase Activities in Wistar Albino Rats

Abstract Views: 681  |  PDF Views: 130

Authors

B. Okwandu Ngozika
Department of Biochemistry, Madonna University Elele Campus, Nigeria
C. Monago Comfort
Department of Biochemistry, University of Port Harcourt Choba, Nigeria
A. Uwakwe Austin
Department of Biochemistry, University of Port Harcourt Choba, Nigeria
J. Ifemeje Chineye
Department of Biochemistry, Anambra State University Uli, Nigeria
U. Okeke Chukwubuike
Department of Prosthesis and Orthopedic Technology, School of Health Technology Federal University of Technology, Owerri, Nigeria

Abstract


The present study was conducted on the rat population of animal house in Madonna University, Elele Campus, Nigeria to evaluate the status of some biochemical parameters of rats administered with varied concentrations of chlorpheniramine maleate (piriton), cyproheptadine hydrochloride (cypron), and clemastine fumarate (tavagyl). Blood samples and liver organ were collected from 51 male and female albino rats, 48 were given different concentrations of each of the antihistamine drugs for 30 days, while 3 rats were used as control. Alanine amino transferase (ALT) activity and Aspartate amino transferase (AST) were lower in the control group compare to the groups administered with piriton, Cypron, and Tavagyl at 0.04mg/ml, 0.02mg/ml, 0.01mg/ml, and 0.005mg/ml. From the above results it is concluded that piriton, cypron, and Tavagyl increased the activities of AST and ALT enzymes.

Keywords


Alanine Amino Transferase, Aspartate Amino Transferase, Piriton, Cypron, and Tavagyl, Rat

References





DOI: https://doi.org/10.17485/ijst%2F2012%2Fv5i7%2F30500