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Antiviral Activity of Vicoa indica against Herpes Simplex Virus


Affiliations
1 Department of Biotechnology, Prince Shri Venkateshwara Arts and Science College, Chennai-600 073, India
2 Centre for Advanced Studies in Botany, University of Madras, Chennai-600 025, India
 

The aim of the present research was focused on the antiviral properties of Vicoa indica (L.) via in vitro approach. The aqueous and methanolic extracts from leaves, stems and ischolar_mains of V. indica (Asteraceae) were tested against HSV - 1 replication. Among these extracts, aqueous extract of ischolar_mains was found to have more potent inhibitory effect. The less concentration (20μg/mL) of methanolic extracts was cytotoxic to vero cell lines. The used concentrations of aqueous extracts were 100 - 50μg/mL. We determined that extract obtained from ischolar_main has higher antiviral effect, and it causes 100 per cent decrease of the virus at IC50 of 100 and 50μg/mL respectively. Further research is needed to elucidate the active constituents of this plant may be useful in the development of new and effective antiviral agents.

Keywords

Asteraceae, Aqueous Extracts, V. indica, HSV-1
User

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  • Antiviral Activity of Vicoa indica against Herpes Simplex Virus

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Authors

A. M. Sabitha Rani
Department of Biotechnology, Prince Shri Venkateshwara Arts and Science College, Chennai-600 073, India
K. Murugesan
Centre for Advanced Studies in Botany, University of Madras, Chennai-600 025, India

Abstract


The aim of the present research was focused on the antiviral properties of Vicoa indica (L.) via in vitro approach. The aqueous and methanolic extracts from leaves, stems and ischolar_mains of V. indica (Asteraceae) were tested against HSV - 1 replication. Among these extracts, aqueous extract of ischolar_mains was found to have more potent inhibitory effect. The less concentration (20μg/mL) of methanolic extracts was cytotoxic to vero cell lines. The used concentrations of aqueous extracts were 100 - 50μg/mL. We determined that extract obtained from ischolar_main has higher antiviral effect, and it causes 100 per cent decrease of the virus at IC50 of 100 and 50μg/mL respectively. Further research is needed to elucidate the active constituents of this plant may be useful in the development of new and effective antiviral agents.

Keywords


Asteraceae, Aqueous Extracts, V. indica, HSV-1

References





DOI: https://doi.org/10.17485/ijst%2F2013%2Fv6i6%2F33921