Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Serum Uric Acid Level in Primigravidae with Pre-Eclampsia:A Case Control Study from Karnataka


Affiliations
1 Kodagu Institute of Medical Sciences, Madikeri, Karnataka, India
2 Dept of OBG, Kodagu Institute of Medical Sciences, Madikeri, Karnataka, India
     

   Subscribe/Renew Journal


Introduction: Pregnancy inducedhypertension is an exclusive condition affecting 10% ofpregnant women. The study of uric acid in serum is an interesting problemespecially in normal pregnancy and pregnancy inducedhypertension (PIH). Objective: To compare the changes of serum uric acid level in healthy non pregnant, PIH and normotensive pregnant women. Methodology: Cross sectional observational study conducted in the Obstetrics and Gynecology department, hospital, Navodaya medical college , Raichur, Karnataka involving 30 each pregnant, PIH and non-pregnant women. Serum uric acid levels were measured and analysed the data using SPSS 23 version software. Results: Comparison ofmean serum uric acid level in pregnant normotensive (4.14±1.05) and in PIH women (6.03±1.61) was found significant. Comparison of mean serum uric acid level in pregnant normotensive women (4.14±1.05) and in non pregnant women ( 3.39±0.5) found significant. Mean serum uric acid level in PIH women was 6.03±1.61 whereas in non pregnant women was 3.39±0.5 (p<0.001). Conclusion:Serum uric acid level is at higher side in PIH women as compared to pregnant normotensives and non pregnant women in our study.


Keywords

Serum Uric Acid, PIH, Preeclampsia, Preganancy.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Shah M R. Hypertensive disorders in pregnancy. 1st edn published by Jaypee. 2007:1-10.
  • Barrilleaux PS, Martin JN; Hypertensive therapy during pregnancy. ClinObstet Gynecol., 2002;45(1):22-34.
  • Cotter AM, Molloy AM, Scott JM, Daly SF. Elevated plasmahomocysteine in early pregnancy: a risk factor for the development of severe preeclampsia. American Journal of Obstetrics and Gynaecology.2001;185(4):781- 85.
  • Dutta D.C (2001), Hypertensive disorders in pregnancy, in :Textbook.
  • Lind T, Godfrey KA, Otun H. Changes in serum uricacid concentration during normal pregnancy. Br Jr of obst and Gyne 1984; 91:128-132.
  • Mustaphi R, Gopalan S, Dhaliwal L, Sarkar AK. Hyperuricaemia and pregnancy induced hypertension-Reappraisal. Ind. J med Sci 1996(3);50:68-71
  • Stander HJ, Cadden JF. Blood chemistry in preeclampsia and eclampsia. Am. J of Obst. Gynecol 1934; 28:856-9.
  • Sietchik J. The metabolism of urate in preclampsia. Am. J of obst Gynecol 1956; 72:40-7.
  • Powers RW, Bodnar LM, Ness RB, Cooper KM, Gallaher MJ, Frank MP, Daftari AR, Roberts JM. Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery. Am J Obstet Gynecol. 2006;194:160:e1– e8.
  • Jeyabalan A, Conrad KP. Renal function during normal pregnancy andpreeclampsia. Front Biosci. 2007;12:2425–2437.
  • Singh AK, Kumar R, Singh VK, Srivastava S, Sharma A. Serum uric acid levels in pregnancy induced hypertension preeclampsia. Int J Clin Biochem Res. 2018;5(3):365-368
  • Jasmin Diwan, Chinmay Shah, Dixit, Anand AK. A Comparative Study of Serum Uric Acid Level in Normal Pregnancy, and Pregnancy Induced Hypertension. Int. J. Med. Public health 2011;1(1): 1 39-41
  • Patel Tejal, Dudhat Astha. Relationship of Serum Uric Acid Level to Maternal and Perinatal Outcome in Patients with Hypertensive Disorders of Pregnancy. Gujarat medical journal 2014 ; 69(2):45-47
  • Hickman PE, Michael CA & Potter JM, Serum uric acidas a marker of pregnancy-induced hypertension. Aust N ZJ Obstet Gynaecol. 1982;22:198-202.
  • Osakwe CR, Ikpeze OC, Ezebialu IU, Osakwe JO& Mbadugha NN, The predictive value of serum uricacid for the occurrence, severity and outcomes of preeclampsiaamong parturients at nnewi Nigeria. Niger J Med. 2015;24(3):192-200.
  • Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, Lan HY, Kivlighn S & Johnson RJ, Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension. 2001;38(5)1101-1106.
  • Shah CJ.serum uric acid levels in PIH. Int. J.Med. Public health,2011;1(1):39-42
  • Lim KH, Friedman SA, Ecker JL, Kao L and. Kilpatrick SJ. The clinical utility of serum uric acid measurements in hypertensivediseases of pregnancy. Am J Obstet Gynecol. 1998 May;178(5):1067-71.

Abstract Views: 515

PDF Views: 0




  • Serum Uric Acid Level in Primigravidae with Pre-Eclampsia:A Case Control Study from Karnataka

Abstract Views: 515  |  PDF Views: 0

Authors

H. C. Veena
Kodagu Institute of Medical Sciences, Madikeri, Karnataka, India
S. Manjunatha
Dept of OBG, Kodagu Institute of Medical Sciences, Madikeri, Karnataka, India

Abstract


Introduction: Pregnancy inducedhypertension is an exclusive condition affecting 10% ofpregnant women. The study of uric acid in serum is an interesting problemespecially in normal pregnancy and pregnancy inducedhypertension (PIH). Objective: To compare the changes of serum uric acid level in healthy non pregnant, PIH and normotensive pregnant women. Methodology: Cross sectional observational study conducted in the Obstetrics and Gynecology department, hospital, Navodaya medical college , Raichur, Karnataka involving 30 each pregnant, PIH and non-pregnant women. Serum uric acid levels were measured and analysed the data using SPSS 23 version software. Results: Comparison ofmean serum uric acid level in pregnant normotensive (4.14±1.05) and in PIH women (6.03±1.61) was found significant. Comparison of mean serum uric acid level in pregnant normotensive women (4.14±1.05) and in non pregnant women ( 3.39±0.5) found significant. Mean serum uric acid level in PIH women was 6.03±1.61 whereas in non pregnant women was 3.39±0.5 (p<0.001). Conclusion:Serum uric acid level is at higher side in PIH women as compared to pregnant normotensives and non pregnant women in our study.


Keywords


Serum Uric Acid, PIH, Preeclampsia, Preganancy.

References