International Journal of Physiology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Serum Thyrotropin Level in Relation to Obesity Indicators in a Clinically Euthyroid Population


Affiliations
1 Demonstrator, Department of Physiology, Gauhati Medical College, Guwahati
2 Professor, Department of Physiology, Gauhati Medical College, Guwahati
3 Professor(Retd.), Department of Endocrinology, Gauhati Medical College, Guwahati
     

   Subscribe/Renew Journal


Minor disturbances of thyroid function, not reaching overt dysfunction, may be associated with the possibility of weight disturbances and the development of obesity. To determine the relation of thyroid function to obesity, a cross-sectional study was carried out among 100 (50 male and 50 female) clinically euthyroid medical students, in the age-group of 18-20 years, at the Gauhati Medical College, Guwahati. The study found a significant positive correlation between serum levels of Thyroid Stimulating Hormone(Thyrotropin, TSH) and waist circumference, hip circumference and waist-hip ratio, both in males and in females.

Keywords

TSH, Waist Circumference, Hip Circumference, Waist-Hip Ratio
Subscription Login to verify subscription
User
Notifications
Font Size


  • Hoogwerf BJ, Nuttall FQ. Long-term weight regulation in treated hyperthyroid and hypothyroid subjects. Am J Med 1984; 76: 963–970

  • Baron DN. Hypothyroidism; its aetiology and relation to hypometabolism , hypercholesterolaemia, and increase in body weight. Lancet 1956; 271: 277–281

  • Jung CH, Sung KC, Shin HS, Rhee EJ, Lee WY, Kim BS, Kang JH, Kim H, Kim SW, Lee MH, Park JR, Kim SW. Thyroid dysfunction and their relation to cardiovascular risk factors such as lipid profile , hsCRP and waist hip ratio in Korea . Korean J Intern Med. 2003 Sep;18(3):146-53

  • Rotondi M, Leporati P, La Manna A, Pirali B, Mondello T, Fonte R, Magri F, Chiovato L. Raised serum TSH levels in patients with morbid obesity: is it enough to diagnose subclinical hypothyroidism? Eur J Endocrinol. 2009 Mar;160(3):403-8

  • http://whqlibdoc.who.int/publications/2011/ 9789241501491_eng.pdf

  • Mehmet Bastemir, Fulya Akin, Esma Alkis, Bunyamin Kaptanoglu. Obesity is associated with increased serum TSH level, independent of thyroid function. Swiss Med Wkly 2007; 137: 431 – 434

  • De Pergola G, Ciampolillo A, Paolotti S, Trerotoli P, Giorgino R. Free triiodithyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women. Clin Endocrinol (Oxf). 2007 Aug;67(2):265-69

  • Riaz M, Salman A, Fawwad A, Iqbal Hydrie MZ, Yakoob Ahmadani M, Basit A, Shera AS. Trends of serum thyrotropin concentration and associated factors in Urban Pakistan (Karachi). Int J Endocrinol Metab. 2009; 1: 12-19

  • Ambrosi B, Masserini B, Iorio L, Delnevo A, Malavazos AE, Morricone L, Sburlati LF, Orsi E. Relationship of thyroid function with body mass index and insulin-resistance in euthyroid obese subjects. J Endocrinol Invest. 2010 Mar 25

  • Anders Svare, Tom IL Nilsen, Trine Bjøro, Bjørn Olav Åsvold and Arnulf Langhammer. Serum TSH related to measures of body mass: longitudinal data from the HUNT Study, Norway. Clin Endocrinol (Oxf). 2011

  • Jose de Jesus Garduno-Garcia, Ulises Alvirde- Garcia, Guadalupe Lopez-Carrasco et al. TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects. Eur J Endocrinol August 1, 2010 163 273-278

  • Reinehr T. Obesity and thyroid function. Mol Cell Endocrinol. 2010 Mar 25;316(2):165-71

  • Petra Kok, Ferdinand Roelfsema, Marijke Frölich, A. Edo Meinders,Hanno Pijl. Spontaneous diurnal thyrotropin secretion is enhanced in proportion to circulating Leptin in obese premenopausal women. The Journal of Clinical Endocrinology and Metabolism. 2005; 90(11): 6185

  • Kok P, Roelfsema F, Langendonk JG, Frölich M, Burggraaf J, Meinders AE, Pijl H 2005 High circulating thyrotropin levels in obese women are reduced after body weight loss induced by caloric restriction. J Clin Endocrinol Metab 90:4659–4663

  • Feldt-Rasmussen U 2007 Thyroid and leptin. Thyroid 17:413–419

  • Menendez C, Baldelli R, Camina JP, et al. TSH stimulates leptin secretion by a direct effect on adipocytes. J Endocrinol. 2003;176:7–12

  • Ortiga-Carvalho TM, Oliveira KJ, Soares BA, Pazos-Moura CC. The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies. J Endocrinol 2002; 174: 121–125

  • Ghizzoni L, Mastorakos G, Ziveri M, Furlini M, Solazzi A, Vottero A et al. Interactions of leptin and thyrotropin 24-h secretory profiles in short normal children. J Clin Endocrinol Metab 2001; 86: 2065–2072

  • Mantzoros CS, Ozata M, Negrao AB, Suchard MA, Ziotopoulou M, Caglayan S et al. Synchronicity of frequently sampled thyrotropin (TSH) and leptin concentrations in healthy adults and leptin-deficient subjects: evidence for possible partial TSH regulation by leptin in humans. J Clin Endocrinol Metab 2001; 86: 3284–3291

  • Santini F, Galli G, Maffei M, Fierabracci P, Pelosini C, Marsili A, Giannetti M, Castagna M, Checchi S, Molinaro E, Piaggi P, Pacini F, Elisei R, Vitti P, Pinchera A. Acute exogenous TSH administration stimulates leptin secretion in vivo. European Journal of Endocrinology 2010; 72: 696–701

  • Oge A, Bayraktar F, Saygili F, Guney E, Demir S 2005 TSH influences serum leptin levels independent of thyroid hormones in hypothyroid and hyperthyroid patients. Endocr J 52:213–217

  • Alqahatani M, Tamimi W, Aldaker M, Alenzi F, Tamim H, Alsadhan A. Young adult reference ranges for thyroid function tests on the Centaur immunoassay analyser. Br J Biomed Sci. 2006; 63(4): 163-5

  • Sceenan S, Caro JF, Refetoff S. Thyroid dysfunction is not associated with alterations in serum leptin levels. Thyroid 1997; 7: 407–409

  • Sorisky A, Bell A, Gagnon A. TSH receptor in adipose cells. Horm Metab Res. 2000;32:468–74

  • Bell A, Gagnon A, Grunder L, Parikh SJ, Smith TJ, Sorisky A. Functional TSH receptor in human abdominal preadipocytes and orbital fibroblasts. Am J Physiol Cell Physiol. 2000;279:C335–40

  • Schaffler A, Binart N, Scholmerich J, Buchler C. Hypothesis paper Brain talks with fat – evidence for a hypothalamic-pituitary-adipose axis? Neuropeptides. 2005;39:363–7

  • Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89: 2548–2556

  • Valyasevi RW, Harteneck DA, Dutton CM, Bahn RS. Stimulation of adipogenesis, peroxisome proliferator-activated receptorgamma (PPARgamma), and thyrotropin receptor by PPARgamma agonist in human orbital preadipocyte fibroblasts. J Clin Endocrinol Metab. 2002;87:2352–8

  • Nils Knudsen, Peter Laurberg, Lone B. Rasmussen, Inge Bülow, Hans Perrild, Lars Ovesen and Torben Jørgensen . Small Differences in Thyroid Function may be important for Body Mass Index and the occurrence of Obesity in the population . The Journal of Clinical Endocrinology and Metabolism . Vol 90; no.7: 4019 – 4024

  • Al-Adsani H, Hoffer LJ, Silva JE 1997 Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. J Clin Endocrinol Metab 82: 1118–1125

  • Dale J, Daykin J, Holder R, SheppardMC, Franklyn JA 2001 Weight gain following treatment of hyperthyroidism. Clin Endocrinol (Oxf) 55:233–239

  • Razvi S, Ingoe L, Keeka G, Oates C, McMillan C, Weaver JU 2007 The beneficial effect of Lthyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin Endocrinol. Metab 92: 1715–1723

  • Tzotzas T, Krassas GE, Konstantinidis T, Bougoulia M 2000 Changes in lipoprotein(a) levels in overt and subclinical hypothyroidism before and during treatment. Thyroid 10:803–808

  • Johansen K, Hansen JM, Skovsted L. Myxoedema and thyrotoxicosis: relations between clinical state and concentrations of thyroxine and triiodothyronine in blood. Acta Med Scand 1978; 204: 361–364

  • Duntas LH. Thyroid disease and lipids. Thyroid 2002; 12: 287–293


Abstract Views: 424

PDF Views: 0




  • Serum Thyrotropin Level in Relation to Obesity Indicators in a Clinically Euthyroid Population

Abstract Views: 424  |  PDF Views: 0

Authors

Anindita Mahanta
Demonstrator, Department of Physiology, Gauhati Medical College, Guwahati
Biju Choudhury
Professor, Department of Physiology, Gauhati Medical College, Guwahati
Sarojini Dutta Choudhury
Professor(Retd.), Department of Endocrinology, Gauhati Medical College, Guwahati

Abstract


Minor disturbances of thyroid function, not reaching overt dysfunction, may be associated with the possibility of weight disturbances and the development of obesity. To determine the relation of thyroid function to obesity, a cross-sectional study was carried out among 100 (50 male and 50 female) clinically euthyroid medical students, in the age-group of 18-20 years, at the Gauhati Medical College, Guwahati. The study found a significant positive correlation between serum levels of Thyroid Stimulating Hormone(Thyrotropin, TSH) and waist circumference, hip circumference and waist-hip ratio, both in males and in females.

Keywords


TSH, Waist Circumference, Hip Circumference, Waist-Hip Ratio

References