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Electrophysiological Evaluation of the Peripheral Nerves of the Upper Extremities in Patients of Chronic Obstructive Pulmonary Disease
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Introduction: Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death, is a major health problem. COPD has been implicated as one of the causes of peripheral neuropathy. The influence of COPD in the peripheral nervous system has been the subject of clinical investigation only in the recent years. This study aimed at evaluating the nerve conduction velocity (NCV) and amplitude of peripheral motor and sensory nerves of the median and ulnar nerves of the upper extremities in patients of COPD when compared to healthy normal subjects.
Material and Method: The subjects (COPD patients and healthy volunteers) were assessed for anthropometric measurements, the pulmonary function tests and SpO2 levels. They were subjected for the nerve conduction test, of the median and ulnar nerves of the upper extremities
Results: A significant decrease in the NCV and amplitude for the median and ulnar nerves (both the components) at p value < 0.001was found in the COPD patients when compared to the control group, irrespective of the causative factor for COPD.
Conclusion: The presence of peripheral neuropathy was confirmed in COPD patients when compared to healthy control group, as the NCV and amplitudes of peripheral nerves (median and ulnar) of the upper extremities were found to be decreased in COPD patients.
Keywords
- Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease. NHLBI/WHO report, NIH, NHLBI publication Number2701 updated 2008. Available from htpp:// www.goldcopd.org/guidelineitem/asp.
- Agust´A G. N. Systemic Effects of Chronic Obstructive Pulmonary Disease. Proc Am Thorac Soc. 2005; 2:367–370. Available at internet address www.atsjournals.org
- Valli G, Barbieri S, Sergi P, Fayoumi Z and Berardinelli P. Evidence of motor neuron involvement in chronic respiratory insufficiency. Journal of Neurology, Neurosurgery, and Psychiatry. 1984; 47: 1117-1121.
- Ozge A, Atis S, Sevim S. Subclinical peripheral neuropathy with chronic obstructive pulmonary disease. Electromyogr Clin Neurophysiol. 2001; 41:185- 191.
- Gupta PP, Agrawal D. Chronic Obstructive Pulmonary Disease and Peripheral Neuropathy. Lung India. 2006; 23: 25-33.
- Stratelis G, Jakobsson P, Molstad S and Zetterstrom O. Early detection of COPD in primary care: screening by invitation of smokers aged 40 to 55 years. British Journal of General Practice.2004; 54: 201-206
- Behera D, Jindal SK. Respiratory symptoms in Indian women using domestic cooking fuels. Chest. 1991; 100: 385-88.
- Mishra UK, Kalita J. Clinical Neurophysiology, 2nd edn. New Delhi Elsevier, Reed Elsevier India Private Limited. 2004:12-218.
- Agrawal D, Vohra R, Gupta PP, Sood S. Subclinical peripheral neuropathy in stable middle-aged patients with chronic obstructive pulmonary disease. Singapore Med J. Oct 2007; 48(10):887-94
- Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The evidence report NIH Publication September 1998; (98): 4083.
- Pfeiffer G, Kunze K, Brüch M, Kutzner M,LadurnerG, MalinJP et al. Polyneuropathy associated with chronic hypoxaemia: prevalence in patients with Chronic Obstructive Pulmonary Disease. J Neurol. 1990; 237: 230-233.
- Alppenzer O, Parks RD, Macgee J. Peripheral Neuropathy in Chronic Disease Of The Respiratory Tract. Am Jour of Med.1968; 44:873- 890.
- McCombe PA and McLeod JG The peripheral neuropathy of vitamin B12 deficiency Journal of the Neurological Sciences. October 1984; 66(1):117-126.
- Narayan M, Ferranti R. Nerve Conduction Impairment In Patients With Respiratory Insufficiency And Severe Chronic Hypoxemia. Arch Phys Med Rehabil.1978; 59: 188-92.
- Kayacan O, Beder S, Deda G, Karnak D. Neurophysiological changes in COPD patients with chronic respiratory insufficiency. Acta Neurol Belg. 2001; 101: 160-165.
- Jann S, Gatti A, Crespi S, Rolo J, Beretta S. Peripheral neuropathy in chronic respiratory insufficiency. J Peripher Nerv Syst. 1998; 3: 69-74.
- Faden A, Mendoza E, Flynn F. Subclinical neuropathy associated with chronic obstructive pulmonary disease possible pathophysiologic role of smoking. Arch Neurol. 1981 Oct; 38(10):639-42.
- Gokhan A, Cakan A, Erbaycu A E, Dereli S, Özsöz A, Edipoðlu H. Electromyographic Evaluation Of Peripheral Nerves In Chronic Obstructive Pulmonary Disease. Turkish Respiratory Journal. Aug 2003; 4(2):51-56.
- MayerP, Dematteis M, PépinJL, WuyamB, VealeD, VilaA, et al. Peripheral Neuropathy In Sleep Apnea A Tissue Marker Of The Severity Of Nocturnal Desaturation. Am J Respir Crit Care Med. Jan 1999; 159(1): 213-219.
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