International Journal of Physiology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Auditory and Neurological Correlation in Auditory and Peripheral Neuropathy in Type II Diabetes Mellitus


Affiliations
1 Senior Resident,Department of Physiology, Maulana Azad Medical College, New Delhi
2 Head of Department of Physiology, Jawaharlal Nehru Medical College, Sawangi, Wardha
3 Head of Department, Department of Physiology, Maulana Azad Medical College, New Delhi
     

   Subscribe/Renew Journal


Background: Diabetes mellitus is metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects of insulin secretion, insulin action or both. The study was conducted with an aim to evaluate the effect of type II Diabetes mellitus on auditory brainstem response and conduction velocity of median nerve(motor component) and sural nerve (sensory component) and to correlate between auditory neuropathy and peripheral neuropathy due to type II Diabetes mellitus. The present study was undertaken in the Neurophysiology Laboratory, Department of Physiology, Jawaharlal Nehru Medical College Sawangi(Meghe) Wardha. It was a cross sectional case control study and a total of 100 subjects were studied out of which 50 were diabetics and 50 were age and sex matched controls. Effective nerve stimulation was obtained by the stimulus duration of 50μs to 1000μs and 0-100mA. Supramaximal stimulation (10-30% more than the current)was given. Electrode impedence was kept below 5k. BAEPs were recorded with the help of a computerized evoked potential recording system by monoaural stimulation and all the parameters have been compared at 70dBnHL stimulus intensityThe duration of diabetes in the study group with mean+S.D. is 6.92+2.08 years. There was no statistical significant difference in mean age and gender between the control group andstudygroup We founded increase in latency of waveV and interpeak latency III-V. There was decreased conduction velocity in median nerve and sural nerve of upper limb and lower limbfor motor nerve and sensory nerve respectively

Keywords

Diabetes Mellitus, Brainstem Auditory Evoked Potential, Nerve Conduction Velocity
Subscription Login to verify subscription
User
Notifications
Font Size


  • World Health Organization1999. Definition, diagnosis and classification of Diabetes Mellitus and its complications. Report of a WHO consultation, PartI.1999:1-31

  • Data from the 2011 National Diabetes Fact Sheet (released Jan. 26, 2011)

  • Lt Gen S R Mehta, ColAS Kashyap et al. Diabetes Mellitus in India: The modern Scourge. MJAFI 2009;65(1);50-54

  • Diabetes Atlas, third edition, International Diabetes Federation,2006. http:// www.eatlas.idf.org/index2983.html.

  • Diabetes fact sheetN312, World Health Organization, November 2008. http:// www.who.int/mediacentre/factsheets/fs312/en.

  • Roy Freeman. The Nervous system and Diabetes. Joslin’s diabetes Mellitus, 14th edition2005:951-968

  • Fujikawa S, Starr A. Vestibular neuropathy accompanying auditory and peripheral neuropathies. Arch Otolaryngol. 2000;126: 1463-1456

  • Misra UK, Kalita J. Clinical Neurophysiology. Reprinted 2008. Published by Elsevier

  • Friedman SA, Schuman RH,WeissS. Hearing and Diabetic neuropathy. Arch Intern Med.1975;135:573-576

  • Lisowska, Gra¿yna,Namys³owski, Grzegorz,Morawski, Krzysztof, Strojek, Krzysztof. Early Identification of Hearing Impairment in Patients With Type 1 Diabetes Mellitus. Otology & Neurotology.2001;22(3): 316-320

  • Luciana L et al Arq Bras Endocrinol Metab2003;47(1):82-86

  • Babin RW, Liu C, Aschenbrener C. Histopathology of neurosensory deafness in sarcoidosis. Ann Otol Rhinol Laryngol. 1984;93:389-393.

  • Terata K, Coppey LJ, Davidson EP, Dunlap JA, Gutterman DD, Yorek MA Acetylcholine-induced arteriolar dilation is reduced in streptozotocininduced diabetic rats with motor nerve dysfunction” Br J Pharmacol. 1999 Oct; 128(3): 837-43.

  • Malik RA, Tesfaye S, Thompson SD, Veves A, Sharma AK, Boulton AJ, Ward JD. Endoneurial localisation of microvascular damage in human diabetic neuropathy. Diabetologia. 1993;36(5):454-9.

  • Malik RA, Veves A, Masson EA, Sharma AK, Ah- See AK, Schady W, Lye RH, Boulton AJ.Endoneurial capillary abnormalities in mild human diabetic neuropathy. J Neurol Neurosurg Psychiatry. 1992;55(7):557-61.

  • Veves A, Donaghue VM, Sarnow MR, Giurini JM, Campbell DR, LoGerfo FW. The impact of reversal of hypoxia by revascularization on the peripheral nerve function of diabetic patients. Diabetologia. 1996 Mar;39(3):344-8.

  • Kennedy JM, Zochodne DW. Impaired peripheral nerve regeneration in diabetes mellitus. J Peripher Nerv Syst. 2005 Jun;10(2):144-57. .

  • Ferrer, J, Birrun, O, Lorenete, J. et al. Auditory function in young patients with type I diabetes mellitus.Diabetes Research and Clinical Practice.1991;11:17-22.

  • Fujikawa and Starr A and others. Auditory Neuropathy. Brain.1996;119:741-753

  • C. Suzuki, I. Ozaki, M. Tanosaki, T. Suda, M. Baba, and M. Matsunaga. Peripheral and central conduction abnormalities in diabetes mellitus. Neurology 2000;54:1932-1937

  • Chi-Re Huang, Chen-Hsien Lu1, Hsueh-Wen Chan, Nan-Wen Tsa, Wen-Neng Chang. Brainstem Auditory Evoked Potentials Study in Patients with Diabetes Mellitus. Acta Neurol Taiwan.2010;19:33-40


Abstract Views: 666

PDF Views: 0




  • Auditory and Neurological Correlation in Auditory and Peripheral Neuropathy in Type II Diabetes Mellitus

Abstract Views: 666  |  PDF Views: 0

Authors

Nandini Agarwal
Senior Resident,Department of Physiology, Maulana Azad Medical College, New Delhi
D A Biswas
Head of Department of Physiology, Jawaharlal Nehru Medical College, Sawangi, Wardha
Rashmi Babbar
Head of Department, Department of Physiology, Maulana Azad Medical College, New Delhi

Abstract


Background: Diabetes mellitus is metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects of insulin secretion, insulin action or both. The study was conducted with an aim to evaluate the effect of type II Diabetes mellitus on auditory brainstem response and conduction velocity of median nerve(motor component) and sural nerve (sensory component) and to correlate between auditory neuropathy and peripheral neuropathy due to type II Diabetes mellitus. The present study was undertaken in the Neurophysiology Laboratory, Department of Physiology, Jawaharlal Nehru Medical College Sawangi(Meghe) Wardha. It was a cross sectional case control study and a total of 100 subjects were studied out of which 50 were diabetics and 50 were age and sex matched controls. Effective nerve stimulation was obtained by the stimulus duration of 50μs to 1000μs and 0-100mA. Supramaximal stimulation (10-30% more than the current)was given. Electrode impedence was kept below 5k. BAEPs were recorded with the help of a computerized evoked potential recording system by monoaural stimulation and all the parameters have been compared at 70dBnHL stimulus intensityThe duration of diabetes in the study group with mean+S.D. is 6.92+2.08 years. There was no statistical significant difference in mean age and gender between the control group andstudygroup We founded increase in latency of waveV and interpeak latency III-V. There was decreased conduction velocity in median nerve and sural nerve of upper limb and lower limbfor motor nerve and sensory nerve respectively

Keywords


Diabetes Mellitus, Brainstem Auditory Evoked Potential, Nerve Conduction Velocity

References