![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltext_open_medium.gif)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltext_restricted_medium.gif)
Saliva, Salivary Gland, Systemic Disease
Subscribe/Renew Journal
As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals with modest training. Gland-specific saliva can be used for diagnosis of pathology specific to one of the major salivary glands. Whole saliva, however, is most frequently used for diagnosis of systemic diseases, since it is readily collected and contains serum constituents. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.
Keywords
Saliva, Salivary Gland, Systemic Disease
Subscription
Login to verify subscription
User
Font Size
Information
- Lima DP, Diniz DG, Moimaz SAS, Sumida DH, Okamoto AC. Saliva: reflection of the body. International Journal of Infectious Diseases (2010); 14: 184–188.
- Tenovuo JO. Salivary parameters of relevance for assesSing caries activity in individuals and populations. Comm Dent Oral Epidemiol 1997;25:82- 6.
- Nauntofte B, Tenevuo JO, Lagerlöf F. Secretion and composition of saliva. In: Fejerskov O and Kidd E, eds. Dental Caries. The disease and its clinical management. Oxford. Blackwell Munksgard; 2003. p. 7-29.
- Hofman LF. Human saliva as a diagnostic specimen. J Nutr 2001;131:1621S-25S.
- Sreebny L, Baum B, Edgar W, Epstein J, Fox P, Larmas M. Saliva: Its role in health and diseases. Int Dent J 1992; 42:291-304.
- Kabir S. Detection of helicobacter pylori DNA in feces and saliva by polymerase chain reaction: a review. Helicobacter. 2004;9:115- 23.
- Schultsz C, Qadri F, Hossain SA, Ahmed F, Ciznar I. Shigellaspecific IgA in saliva of children with bacillary dysentery. FEMS Microbiol Immunol. 1992;4:65–72.
- Schwartz BS, Ford DP, Childs JE, Rothman N, Thomas RJ. Anti- tick saliva antibody: a biologic marker of tick exposure that is a risk factor for Lyme disease seropositivity. Am J Epidemiol.1991;134:86–95.
- Bueno EC, Vaz AJ, Machado LD, Livramento JA. Neurocysticercosis: detection of IgG, IgA and IgE antibodies in cerebrospinal fluid, serum and saliva samples by ELISA with Taenia solium and Taenia crassiceps antigens. Arq Neuropsiquiatr. 2000;58:18-24.
- Malamud D. Oral diagnostic testing for detecting human immunodeficiency virus-1 antibodies: a technology whose time has come. Am J Med. 1997;102:9–14.
- Cordeiro ML, Turpin CS, McAdams SA. A comparative study of saliva and OraSure oral fluid. Ann NY Acad Sci.1993;694:330–1.
- Oba IT, Spina AM, Saraceni CP, Lemos MF, Senhoras R, Moreira RC, et al. detection of hepatitis A antibodies by ELISA using saliva as clinical samples. Rev Inst Med Trop Sao Paulo. 2000;42:197- 200.
- Zhang YL, Pan HY, Chen CR, Lou GQ, YE RX, Lu DR. The roles of saliva testing for preventing hepatitis B virus spreading. Zhonghua Yu Fang Yi Xue Za Zhi. 2008;42:596-8.
- Jin L, Vyse A, Brown DW. The role of RT-PCR assay of oral fluid for diagnosis and surveillance of measles, mumps and rubella. Bull World Health Organ. 2002;80:76-7.
- Aiyar J, Bhan MK, Bhandari N, Kumar R, Raj P, Sazawal S. Rotavirus- specific antibody response in saliva of infants with rotavirus diarrhea. J Infect Dis. 1990;162:1383-4.
- Lazarini PR, Vianna MF, Alcantara MP, Scalia RA, Caiaffa Filho HH. Herpes simplex virus in the saliva of peripheral Bell’s palsy patients. Braz J Otorhinolaryngol. 2006;72:7-11.
- Chakravarti A, Matlani M, Jain M. Immunodiagnosis of dengue virus infection using saliva. Curr Microbiol. 2007;55:461-4.
- Slomiany BL, Aono M, Murty VL, Slomiany A, Levine MJ, Tabak LA. Lipid composition of submandibular saliva from normal and cystic fibrosis individuals. J Dent Res. 1982;61:1163–6.
- Ueshiba H, Zerah M, new MI. Enzyme-linked immunosorbent assay (ELISA) method for screening of non-classical steroids 21-hydroxylase deficiency. Horm Metab Res. 1994;26:43-5.
- Iwasaki K, Okawa-Takatsuji M, Aotsuka S, Ono T. Detection of anti-SS-A/Ro and anti-SS-B/La antibodies of IgA and IgG isotypes in saliva and sera of patients with Sjogren’s syndrome. Nihon Rinsho Meneki Gakkai Kaishi. 2003;26:346-54.
- Lenander-Lumikari M, Loimaranta V. Saliva and dental caries. Adv Dent Res. 2000;14:40-7.
- Van Nieuw Amerongen A, Bolscher JG, Veerman EC. Salivary proteins: protective and diagnostic value in cariology? Caries Res.2004;38:247-53.
- Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal disease. Lancet. 2005;366:1809-20.
- Morrison HI, Ellison LF, Taylor GW. Periodontal disease and risk of fatal coronary heart and cerebrovascular disease. J Cardiovasc Risk. 1999;6:7- 11.
- Rees TD. Drugs and oral disorders. Periodontol 2000. 1998;18:21–36.
- Epstein JB, Gorsky M, Guglietta A, Le N, Sonis ST. The correlation between epidermal growth factor levels in saliva and the severity of oral mucositis during oropharyngeal radiation therapy. Cancer. 2000;89:2258-65.
- Mittal S, Bansal V, Garg S, Atreja G, Bansal S. The diagnostic role of Saliva - A Review. J Clin Exp Dent. 2011;3(4):e314-20.
- Vasudev A, Tripathi KD, Puri V. Correlation of serum and salivary carbamazepine concentration in epileptic patients: implications for therapeutic drug monitoring. Neurol India. 2002;50:60- 2.
![](https://i-scholar.in/public/site/images/abstractview.png)
Abstract Views: 645
![](https://i-scholar.in/public/site/images/pdfview.png)
PDF Views: 0