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Neuroprotection of the Striatal Dopaminergic Neurons by Tempol in Aged Rat Model of Parkinson's Disease


Affiliations
1 Department of Physiology, Maulana Azad Medical College, New Delhi, India
2 Department of Pathology, G B Pant Hospital, New Delhi, India
3 Department of Physiology, Maulana Azad Medical College, New Delh, India
     

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In the present study, the potential of tempol has been examined as a neuroprotective agent against the toxicity of the 6-hydroxydopamine (6-OHDA) in aged rat. Literature is silent about it. Sprague- Dawley rats were pretreated with tempol and subsequently administered the neurotoxin 6-OHDA into the aged rat striatum. Various behavior and immunohistochemical tests were used to evaluate the neuroprotective effect of tempol. Significant difference in various groups was found (ANOVA, p<0.001) in apomorphine-induced rotational behavior, staircase test success rate&disengage time and (ANOVA, p<0.05) in stepping test, initiation time&postural balance test. On the basis of immunohistochemical changes, the present study concludes that tempol is an effective neuroprotective agent for dopaminergic neurons in 6-OHDA induced aged rat model of Parkinson's disease (PD). Aged rats showed less neuroprotection in dopaminergic neurons loss than young rats

Keywords

Tempol, 6-hydroxydopamine And Aged Rat
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  • Neuroprotection of the Striatal Dopaminergic Neurons by Tempol in Aged Rat Model of Parkinson's Disease

Abstract Views: 433  |  PDF Views: 0

Authors

Manisha Gautam
Department of Physiology, Maulana Azad Medical College, New Delhi, India
Shalu Nim
Department of Physiology, Maulana Azad Medical College, New Delhi, India
Ravinder Kumar Saran
Department of Pathology, G B Pant Hospital, New Delhi, India
Bal Krishana
Department of Physiology, Maulana Azad Medical College, New Delh, India

Abstract


In the present study, the potential of tempol has been examined as a neuroprotective agent against the toxicity of the 6-hydroxydopamine (6-OHDA) in aged rat. Literature is silent about it. Sprague- Dawley rats were pretreated with tempol and subsequently administered the neurotoxin 6-OHDA into the aged rat striatum. Various behavior and immunohistochemical tests were used to evaluate the neuroprotective effect of tempol. Significant difference in various groups was found (ANOVA, p<0.001) in apomorphine-induced rotational behavior, staircase test success rate&disengage time and (ANOVA, p<0.05) in stepping test, initiation time&postural balance test. On the basis of immunohistochemical changes, the present study concludes that tempol is an effective neuroprotective agent for dopaminergic neurons in 6-OHDA induced aged rat model of Parkinson's disease (PD). Aged rats showed less neuroprotection in dopaminergic neurons loss than young rats

Keywords


Tempol, 6-hydroxydopamine And Aged Rat