Indian Journal of Chemical Technology

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Voltammetric Investigations of Functional Dyspepsia Drug Acotiamide at Pencil Graphite Electrode: An Eco-Friendly and Cost Effective Stripping Detection Method


Affiliations
1 Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur-302 004, India
2 Department of Chemistry, Shri Bhawani Niketan PG College, Jaipur, Rajasthan, India
 

First time, the electro-oxidative behaviour and determination of acotiamide at a pencil graphite electrode have been investigated under different experimental conditions using cyclic voltammetry (CV), differential pulse anodic stripping voltammetry (DPASV), and square wave anodic stripping voltammetric (SWASV) techniques. The voltammetric responses of acotiamide have been analyzed at different scan rates, pH and concentrations. Oxidation of acotiamide at the surface of pencil graphite electrode gave two well defined irreversible peaks in the voltammograms in BR buffer of pH 7.0. The oxidation process is completely diffusion controlled. A linear response of peak current has been obtained between 15.5 to 124 μM in non-aqueous media for all the voltammetric techniques. The proposed DPASV and SWASV techniques show limit of detection at 18.58 and 13.36 μM, respectively.

Keywords

Acotiamide, BR Buffer, Functional Dyspepsia, Pencil Graphite Electrode, Stripping Voltammetry.
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  • Voltammetric Investigations of Functional Dyspepsia Drug Acotiamide at Pencil Graphite Electrode: An Eco-Friendly and Cost Effective Stripping Detection Method

Abstract Views: 70  |  PDF Views: 58

Authors

Rinky Agarwal
Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur-302 004, India
Rajesh Yadav
Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur-302 004, India
Raj Kumar Sharma
Department of Chemistry, Shri Bhawani Niketan PG College, Jaipur, Rajasthan, India
D. K. Sharma
Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur-302 004, India
K. K. Jhankal
Electrochemical Sensor Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur-302 004, India

Abstract


First time, the electro-oxidative behaviour and determination of acotiamide at a pencil graphite electrode have been investigated under different experimental conditions using cyclic voltammetry (CV), differential pulse anodic stripping voltammetry (DPASV), and square wave anodic stripping voltammetric (SWASV) techniques. The voltammetric responses of acotiamide have been analyzed at different scan rates, pH and concentrations. Oxidation of acotiamide at the surface of pencil graphite electrode gave two well defined irreversible peaks in the voltammograms in BR buffer of pH 7.0. The oxidation process is completely diffusion controlled. A linear response of peak current has been obtained between 15.5 to 124 μM in non-aqueous media for all the voltammetric techniques. The proposed DPASV and SWASV techniques show limit of detection at 18.58 and 13.36 μM, respectively.

Keywords


Acotiamide, BR Buffer, Functional Dyspepsia, Pencil Graphite Electrode, Stripping Voltammetry.

References