Indian Journal of Chemical Technology

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Synthesis and Characterization of Graphene Nanosheets for Electrochemical Quantification of Chlorpheniramine Maleate Drugs Using a Modified Glassy Carbon Electrode


Affiliations
1 Department of Physical Chemistry, School of Chemical Sciences, University of Madras, Chennai 600 025, Tamil Nadu,, India
 

The development of innovative sensors for the detection of analytes at extremely low concentrations with great sensitivity and selectivity has been a major focus of this study. The electrochemical activity of chlorpheniramine maleate (CPRM) in the presence of a graphene modified GCE has been investigated. Cyclic voltammograms (CV) have been obtained in the linear dynamic range 3.5- 156 μM while the optimum pH range and the maximum peak current (IPa) have been measured at pH 7.3. The process on the electrode's surface, diffusion regulated, heterogeneous rate constant, charge transfer coefficient, and the number of electrons transferred among the physicochemical properties have been obtained. Differential pulse voltammetry (DPV) of CPRM at the modified has electrode revealed a good linear calibration curve with a linear range of 10 to 60 μM and limit of detection of 0.062 μM. The suggested sensor has been fabricated and utilized to determine CPRM in medicines as well as serum samples.

Keywords

Chlorpheniramine maleate, Electrochemical sensor, Graphene@GCE, Ullman method
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  • Synthesis and Characterization of Graphene Nanosheets for Electrochemical Quantification of Chlorpheniramine Maleate Drugs Using a Modified Glassy Carbon Electrode

Abstract Views: 80  |  PDF Views: 74

Authors

E Murugan
Department of Physical Chemistry, School of Chemical Sciences, University of Madras, Chennai 600 025, Tamil Nadu,, India
A Poongan
Department of Physical Chemistry, School of Chemical Sciences, University of Madras, Chennai 600 025, Tamil Nadu,, India
M Kesava
Department of Physical Chemistry, School of Chemical Sciences, University of Madras, Chennai 600 025, Tamil Nadu,, India
A Vinitha
Department of Physical Chemistry, School of Chemical Sciences, University of Madras, Chennai 600 025, Tamil Nadu,, India

Abstract


The development of innovative sensors for the detection of analytes at extremely low concentrations with great sensitivity and selectivity has been a major focus of this study. The electrochemical activity of chlorpheniramine maleate (CPRM) in the presence of a graphene modified GCE has been investigated. Cyclic voltammograms (CV) have been obtained in the linear dynamic range 3.5- 156 μM while the optimum pH range and the maximum peak current (IPa) have been measured at pH 7.3. The process on the electrode's surface, diffusion regulated, heterogeneous rate constant, charge transfer coefficient, and the number of electrons transferred among the physicochemical properties have been obtained. Differential pulse voltammetry (DPV) of CPRM at the modified has electrode revealed a good linear calibration curve with a linear range of 10 to 60 μM and limit of detection of 0.062 μM. The suggested sensor has been fabricated and utilized to determine CPRM in medicines as well as serum samples.

Keywords


Chlorpheniramine maleate, Electrochemical sensor, Graphene@GCE, Ullman method

References