Journal of Natural Remedies

Open Access Open Access  Restricted Access Subscription Access

Formulation and Standardization of Polyherbal Antihyperlipidemic Formulation


Affiliations
1 Department of Chemistry, School of Advanced Sciences, VIT University, Vellore – 632014, Tamil Nadu, India
2 Department of Chemistry, VIT University, Vellore – 632014, Tamil Nadu, India
 

Hyperlipidemia is a very common medical condition. A fairly less invasive, more effective and efficient method with lower or no side effects to treat Hyperlipidemia are to be developed. Thus, use of traditional herbal medication can be a relevant solution to it. Development of highly standardized Polyherbal formulation with respect to chemical content and therapeutic activity is considered as a valuable approach in the field of herbal industry. Traditional medicine is known for its Polyherbal contents and multicomponent therapeutics for managing health problems. Thus, the present research is focused on to formulate, standardize a polyherbal medicine to treat hyperlipidemia and also compared its chemical contents based on, geographical, seasonal variations using standard physio-chemical parameters such as Ash values, Extractive values, pH, and loss on drying, Particle size analysis and physical analysis of powder formulation. HPTLC fingerprinting, with markers such as Gallic acid, Quercetin, Gymnemic acid, and Mahanine were carried out. In addition, residue analysis such as heavy metal content, microbial load, pesticide analysis, aflotoxin determination were also carried out to strengthen the standardization process and to ensure safety.

Keywords

Antihyperlipidemic, HPTLC Profiling, Physico-chemical Parameters, Polyherbal, Standardization
Font Size

User

Notifications
JOURNAL COVERS
  

  • Shattat GF. A review article on hyperlipidemia: Types, treatments and new drug targets. Biomedical and Pharmacology Journal. 2014; 7(2):399–409. https://doi.org/10.13005/ bpj/504

  • Ahmed A, Mustofa MJ. Role of soft law in environmental protection: An overview. Global Journal of Politics and Law Research. 2016; 4(2):1–18.

  • Smith TC. The neomuran origin of archaebacteria, the negibacterial root of the universal tree and bacterial megaclassification. International Journal of Systamatic and Evolutionary Microbiology. 2002; 52(1):7–76. https://doi. org/10.1099/00207713-52-1-7. PMid:11837318

  • Society for Vascular Surgery. Hyperlipidemia [Internet]. [cited 2019 Nov 10]. Available from: https//vascular.org/ patient-resources/vascular-conditions/hyperlipidemia.

  • Kramer W. Antilipidemic drug therapy today and in the future. Handbook of Experimental Pharmacology. 2015 :251–63. https://doi.org/10.1007/164_2015_15. PMid:26330256 PMCid:PMC7122375

  • Collins R, Reith C, Emberson J, Armitage J, Baigent C, Blackwell L et al. Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet. 2016; 388(10059):2532–61. https://doi.org/10.1016/S0140- 6736(16)31357-5

  • Meeusen JW, Donato LJ, Jaffe AS. Should apolipoprotein B replace LDL cholesterol as therapeutic targets are lowered? Current Opinion in Lipidology. 2016; 27(4):359–66. https://doi.org/10.1097/MOL.0000000000000313. PMid:27389631

  • Brown JM. No foie gras with apolipoprotein B inhibitors? Science Translational Medicine. 2016; 8(357). https://doi. org/10.1126/scitranslmed.aah7024

  • Dhrubajyoti B, Ashish K, Adrija H, Arshna Q, K. Ghosh R. Science Translational Medicine. Journal of Lipids. 2018:1– 13. https://doi.org/10.1155/2018/3179201. PMid:29770231 PMCid:PMC5889852

  • Hernáez Á, Castañer O, Elosua R, Pinto X, Estruch R, Salas-Salvado J, et al. Mediterranean diet improves highdensity lipoprotein function in high-cardiovascular-risk individuals. Circulation. 2017; 135(7):633–43. https:// doi.org/10.1161/CIRCULATIONAHA.116.023712. PMid:28193797

  • Ko DT, Alter DA, Guo H, Koh M, Lau G, Austin PC, et al. High-density lipoprotein cholesterol and cause-specific mortality in individuals without previous cardiovascular conditions: The CANHEART study. Journal of American College of Cardiology. 2016; 68(19):2073–83. https://doi. org/10.1016/j.jacc.2016.08.038. PMid:27810046

  • Canfrán-Duque A, Lin CS, Goedeke L, Suárez Y, Fernández- Hernando C. Micro-RNAs and high-density lipoprotein metabolism. Arteriosclerosis Thrombosis Vascular Biology. 2016; 36(6):1076–84. https://doi.org/10.1161/ATVBAHA.1 16.307028. PMid:27079881 PMCid:PMC5315356

  • Karole S, Shrivastava S, Thomas S, Soni B, Khan S, Dubey S, et al. Polyherbal Formulation Concept for Synergic Action: A Review. Journal of Drug Delivery and Therapeutics. 2019; 9(1). https://doi.org/10.22270/jddt.v9i1-s.2339

  • Martins E. The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. National Centre for Biotechnology Information. 2014; 4. https://doi.org/10.3389/fphar.2013.00177. PMid:24454289 PMCid:PMC3887317

  • Ekka N, Nmedo K. Standardization strategies for herbal drugs. Research Journal of Pharmacy and Technology. 2008; 1:301–12.

  • Bhargava VV, Saluja AK, Dholwani KK. Detection of heavy metal contents and proximate analysis of roots of Anogeissus latifolia. Journal of Pharmacognosy and Phytochemistry. 2013; 1(6):61–5.

  • Manallack DT, Prankerd RJ, Yuriev E, Oprea TI, Chalmers DK. The Significance of acid/base properties in drug discovery. National Centre for Biotechnology Information. 2014; 42(2):485–96. https://doi.org/10.1039/C2CS35348B. PMid:23099561 PMCid:PMC3641858

  • Sun Z, Ya N, Adams RC, Fang FS. Particle size specifications for solid oral dosage forms: A regulatory perspective. American Pharmaceutical Review. 2010; 13(4).

  • Rajalakshmi P, Sudeer RG, Vadivel V, Sahayam CS, Brindha P. Analytical studies on Annabethi Chenthuram, A Siddha Herbomineral Formulation. Indian Journal of Pharmaceutical Science. 2017; 79(6):987–93. https://doi. org/10.4172/pharmaceutical-sciences.1000316

  • Madhu C, Krishna KM, Reddy KR, Lakshmi PJ, Eswar KK. Estimation of crude fibre content from natural food stuffs and its laxative activity induced in rats. International Journal of Pharma Research and Health Science. 2017; 5(3):1703–6. https://doi.org/10.21276/ijprhs.2017.03.04

  • Shah RB, Tawakkul MA, Khan MA. Comparative evaluation of flow for pharmaceutical powders and granules. National Centre for Biotechnology Information. 2008; 9(1):250–8. https://doi.org/10.1208/s12249-008-9046-8. PMid:18446489 PMCid:PMC2976911

  • Gaikwad A, More N, Wele A. Bulk density and tapped density of powders. International Journal of Ayurveda Pharma Research. 2015; 3(10):2322–902.

  • Thomas MA. Importance of powder density in solid dosage form [Internet]. 2019 [cited 2019 Nov 24]. Available from: https://www.pharmaceuticalonline.com/doc/importanceof- powder-density-in-solid-dosage-0001.

  • Al-Hashemi HMB, Al-Amoudi OSB. A review on the angle of repose of granular materials. Elsevier. 2018; 330:397–417. https://doi.org/10.1016/j.powtec.2018.02.003

  • Insight Medical Publishing. Phytochemical screening [Internet]. 2019 [cited 2019 Nov 24]. Available from: http:// www.imedpub.com/scholarly/phytochemical-screeningjournals- articles-ppts-list.php.

  • Kulkarni NM. Detection of heavy metals in azathiorpine api drugs. International Journal of Chemical Physics Science. 2018; 7(3):88. https://doi.org/10.30731/ijcps.7.3.2018.88-91

  • Tchounwou P, Yedjou C, Patlolla A, Sutton D. Heavy metal toxicity and the environment. National Centre for Biotechnology Information. 2012; 101:133–64. https:// doi.org/10.1007/978-3-7643-8340-4_6. PMid:22945569 PMCid:PMC4144270

  • Pacific BioLabs. Microbial Limits Test. [Internet]. 2019 [cited 2019 Nov 24]. Available from: https://pacificbiolabs. com/microbial-limits-testing.

  • Department of Food Safety and Zoonoses. Aflatoxins; 2018.

  • Gopa B, Bhatt J, Hemavathi KG. A comparative clinical study of hypolipidemic efficacy of Amla (Emblica officinalis) with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitor simvastatin. Indian Journal of Pharmacology. 2012; 44(2):238–42. https://doi.org/10.4103/0253-7613.93857. PMid:22529483 PMCid:PMC3326920

  • Lama A, Saikia H. The effects of Emblica officinalis on serum lipids and atherogenesis, in albino rats fed with high fat diet. International Journal Pharma Professionals Research. 2011; 2(2).

  • Ikarashi N, Toda T, Okaniwa T, Ito K, Ochiai W, Sugiyama K. Anti-obesity and anti-diabetic effects of acacia polyphenol in obese diabetic KKAy mice fed high-fat diet. Evidence- Based Complementary and Alternative Medicine. 2011. https://doi.org/10.1093/ecam/nep241. PMid:21799697 PMCid:PMC3137845

  • Kirtikar K, Basu B. Indian medicinal plants - III. 3rd ed. Dehradun, India: International Book Distributors; 1998.

  • Kapoor LD. Handbook of Ayurvedic Medicinal Plants: Herbal Reference Library. 1st ed. CRC Press, Taylor & Francis Group; 2000.

  • Dineshkumar B, Mitra A, Mahadevappa M. Antidiabetic and Hypolipidemic Effects of Mahanimbine (Carbazole Alkaloid) From Murraya Koenigii (Rutaceae) Leaves. International Journal of Phytomedicine. 2010; 2(1).

  • Tandon N, Sharma P. Quality Standards of Indian Medicinal Plants. 3rd ed. Indian Council of Medical Research; 2005.

  • Wagner H, Bladt S, Zgainski EM. Plant drug analysis - a thin layer chromatography atlas. New York: Springer; 1986. doi.org/10.1002/jobm.3620260220.

  • Basu BD, Kirtikar KR. Indian Medicinal Plants. New Delhi: Periodical Experts Book Agenc; 2012.


Abstract Views: 138

PDF Views: 86




  • Formulation and Standardization of Polyherbal Antihyperlipidemic Formulation

Abstract Views: 138  |  PDF Views: 86

Authors

S. L. Manju
Department of Chemistry, School of Advanced Sciences, VIT University, Vellore – 632014, Tamil Nadu, India
Smitha Rani
Department of Chemistry, VIT University, Vellore – 632014, Tamil Nadu, India

Abstract


Hyperlipidemia is a very common medical condition. A fairly less invasive, more effective and efficient method with lower or no side effects to treat Hyperlipidemia are to be developed. Thus, use of traditional herbal medication can be a relevant solution to it. Development of highly standardized Polyherbal formulation with respect to chemical content and therapeutic activity is considered as a valuable approach in the field of herbal industry. Traditional medicine is known for its Polyherbal contents and multicomponent therapeutics for managing health problems. Thus, the present research is focused on to formulate, standardize a polyherbal medicine to treat hyperlipidemia and also compared its chemical contents based on, geographical, seasonal variations using standard physio-chemical parameters such as Ash values, Extractive values, pH, and loss on drying, Particle size analysis and physical analysis of powder formulation. HPTLC fingerprinting, with markers such as Gallic acid, Quercetin, Gymnemic acid, and Mahanine were carried out. In addition, residue analysis such as heavy metal content, microbial load, pesticide analysis, aflotoxin determination were also carried out to strengthen the standardization process and to ensure safety.

Keywords


Antihyperlipidemic, HPTLC Profiling, Physico-chemical Parameters, Polyherbal, Standardization

References