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Genotoxicity Assessment of Hydroalcoholic Extract of Bark of Terminalia arjuna (Combretaceae)


Affiliations
1 Department of Chemistry, School of Advanced Sciences, VIT, Vellore – 632014, Tamil Nadu, India
 

The mutagenic potential of Terminalia arjuna hydroalcoholic bark extract was evaluated using Ames test with strains TA98, TA100, TA102, TA1535, and TA1537. The genotoxic potential was assessed by performing Chromosomal Aberration test with cell lines of CHO. In the assessment of mutagenic potential by the Ames test, hydroalcoholic extract of Terminalia arjuna induced a negative response and in Chromosomal Aberration test, it did not show any significant genotoxic activity in the CHO cell lines.

Keywords

Ames Test, Chromosomal Aberration Test, CHO Cell Lines, Hydroalcoholic Extract, Terminalia arjuna
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  • Genotoxicity Assessment of Hydroalcoholic Extract of Bark of Terminalia arjuna (Combretaceae)

Abstract Views: 150  |  PDF Views: 78

Authors

Alex Thomas
Department of Chemistry, School of Advanced Sciences, VIT, Vellore – 632014, Tamil Nadu, India
K. R. Ethiraj
Department of Chemistry, School of Advanced Sciences, VIT, Vellore – 632014, Tamil Nadu, India

Abstract


The mutagenic potential of Terminalia arjuna hydroalcoholic bark extract was evaluated using Ames test with strains TA98, TA100, TA102, TA1535, and TA1537. The genotoxic potential was assessed by performing Chromosomal Aberration test with cell lines of CHO. In the assessment of mutagenic potential by the Ames test, hydroalcoholic extract of Terminalia arjuna induced a negative response and in Chromosomal Aberration test, it did not show any significant genotoxic activity in the CHO cell lines.

Keywords


Ames Test, Chromosomal Aberration Test, CHO Cell Lines, Hydroalcoholic Extract, Terminalia arjuna

References





DOI: https://doi.org/10.18311/jnr%2F2023%2F28309