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Anti Anti-obesity and Antihyperlipidemic Activity of Ougeinia oojeinensis (Roxb.) in High Fat Diet-Induced Obesity in Experimental Animals


Affiliations
1 KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh, India
2 Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra, India
 

The present study was planned to assess the anti-obesity efficacy of petroleum ether, ethyl acetate, and methanolic extracts of leaves of Ougeinia oojeinensis (Roxb.) belonging to the family Fabaceae. The soxhlation method was employed to produce the extracts. Wistar rats were subjected to a high-fat diet for 40 days to induce obesity. Along with the high-fat diet, a standard drug Orlistat 50 mg/kg and various extracts of O. oojeinensis at 100 mg/kg and 200 mg/kg were administered for 40 days. The key markers like lipid profiles, SGOT, SGPT, glucose, body weight, food intake, body temperature, atherogenic index, coronary index, and weight of the organs were assessed. The anti-antioxidant properties like TBARS, GSH, GR, Gpx, SOD, and CAT were also estimated. The results revealed that O. oojeinensis with the doses 100 and 200 mg/kg showed significant Anti obese and hypolipidemic effects in rats fed with a high-fat diet.

Keywords

Antihyperlipidemic Anti-Obesity, Antioxidant, Lipid Profile, O. oojeinensis.
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  • Anti Anti-obesity and Antihyperlipidemic Activity of Ougeinia oojeinensis (Roxb.) in High Fat Diet-Induced Obesity in Experimental Animals

Abstract Views: 159  |  PDF Views: 77

Authors

K. Jagadeeshwar
KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh, India
R. Subhakara Raju
KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh, India
G. Chakravarthi
KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh, India
A. Rajasekhar Reddy
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra, India
G. S. N. Koteswara Rao
Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, VL Mehta Road, Vile Parle (W), Mumbai - 400056, Maharashtra, India
Narender Malothu
KL College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur – 522502, Andhra Pradesh, India

Abstract


The present study was planned to assess the anti-obesity efficacy of petroleum ether, ethyl acetate, and methanolic extracts of leaves of Ougeinia oojeinensis (Roxb.) belonging to the family Fabaceae. The soxhlation method was employed to produce the extracts. Wistar rats were subjected to a high-fat diet for 40 days to induce obesity. Along with the high-fat diet, a standard drug Orlistat 50 mg/kg and various extracts of O. oojeinensis at 100 mg/kg and 200 mg/kg were administered for 40 days. The key markers like lipid profiles, SGOT, SGPT, glucose, body weight, food intake, body temperature, atherogenic index, coronary index, and weight of the organs were assessed. The anti-antioxidant properties like TBARS, GSH, GR, Gpx, SOD, and CAT were also estimated. The results revealed that O. oojeinensis with the doses 100 and 200 mg/kg showed significant Anti obese and hypolipidemic effects in rats fed with a high-fat diet.

Keywords


Antihyperlipidemic Anti-Obesity, Antioxidant, Lipid Profile, O. oojeinensis.

References





DOI: https://doi.org/10.18311/jnr%2F2023%2F32197