Androgenic Activity of the Total Alkaloid Fraction of Alangium salviifolium (Linn.F)

Objective: To perform the androgenic and anti-androgenic activity of the total alkaloid fraction of Alangium salviifolium (Family: Alangiaceae). Materials and methods: The total alkaloid fraction of the methanolic extract of stem bark of Alangium salviifolium was used for the experiment. Immature male albino rats received orally a dose of 10 mg and 20 mg/kg body weight of the fraction for 7 days. The weight of the reproductive organs of the treated rats was measured on the eighth day of the treatment and histometric measurements were carried out. Results: A significant increase in the weight of testis, seminal vesicles, ventral prostate and epididymis was observed in the treated rats. Conclusion: The results suggest the androgenic behaviour of the total alkaloid fraction.