Anti-ulcer Activity of Caesalpinia bonducella (Linn.) Flem. Leaves

The purpose of the present study is to evaluate the anti-ulcer activity of Caesalpinia bonducella (Linn.) Flem. The methanolic extract of Caesalpinia bonducella (Linn.) Flem. leaves were evaluated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer (antisecretory) in rats, water immersion stress induced ulcer models in rats and HCl-Ethanol induced ulcer (cytoprotective) in mice at two different doses viz. 100 and 200 mg/ kg. Biochemical parameters like volume, pH, free acidity, total acidity of the gastric juice, ulcer index and percentage protection were studied. The methanolic extract of Caesalpinia bonducella leaves in aspirin plus pyrolus ligation showed significant (P<0.05, P<0.01) reduction in gastric volume, free acidity, total acidity and ulcer index at dose of 100 and 200 mg/kg as compared to control, there was marked increase in pH at dose of 100 and 200 mg/kg. The plant extract at both dose of 100 and 200 mg/kg showed significant gastro protective activity in water immersion stress induced ulcer and HCl-Ethanol induced ulcer. Thus, the present results indicate that the methanolic extract of Caesalpinia bonducella (Linn.) Flem. leaves have significant anti-ulcer activity.