Refine your search
Collections
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Zuraini, A.
- Effects of Neem (Azadirachta indica) Leaf Extracts on Lipid and C-reactive Protein Concentrations in Cholesterol-fed Rats
Abstract Views :587 |
PDF Views:460
Authors
Source
Journal of Natural Remedies, Vol 6, No 2 (2006), Pagination: 109-114Abstract
Objectives: Aim of this study is to investigate the effects of Neem (Azadirachta indica) leaf extract on serum lipid parameters and C-reactive protein (CRP) concentrations. The association between CRP and serum lipid profiles in hypercholesterolemic rats is also investigated. Methods: Total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG) and CRP were measured at week 0, 2, 4, 6 and 8 in 4 groups of animals; the control group (C), cholesterol control group (CC), cholesterol-fed groups treated with Neem leaf extract at doses of 50 and 300 mg/kg/day orally (N1&N2), respectively. Results: Cholesterol feeding had resulted in a significant increase (p<0.05) in TC, LDL&TG in group CC starting from week 2 and a decrease in HDL levels (p<0.05). CRP concentrations also showed a significant increment in the cholesterol-treated rats (CC) compared to group C, N1&N2 (p<0.05). Neem extract treated, TC, LDL and TG levels remained within the normal range similar to Group C and CRP concentrations were lowered but HDL levels were not. Conclusions: It is shown in this study that the concentrations of CRP had increased in CC rats but not in rats with normal cholesterol levels. Neem extract at 50 and 300 mg/kg doses had prevented the rise of TC, LDL and TG in cholesterol-fed rats. No significant changes in CRP concentrations were noted in the Neem-treated animals. Association between CRP and serum lipid concentrations is directly proportionate. They also suggest that Neem leaf extracts at 50 and 300 mg/kg concentrations are excellent lipid-lowering agent.Keywords
Neem, C-reactive Protein, Serum Lipid, Hypercholesterolemia- Gastroprotective Activity of Spirulina platensis in Acetic Acid and Ethanol Induced Ulcers in Rats
Abstract Views :470 |
PDF Views:389
Authors
M. N. Somchit
,
S. Siti Rahmah
,
A. Zuraini
,
A. Ahmad Bustamam
,
Z. A. Zakaria
,
N. Somchit
,
L. Shamsuddin
Source
Journal of Natural Remedies, Vol 7, No 1 (2007), Pagination: 37-42Abstract
Objective: The effects of gastroprotective properties of Spirulina platensis was investigated in acetic acid and ethanol induced ulcers in rats. Methods: Administration of 2 and 4mg/kg Spirulina platensis extract for 7 days. After day 7, oral administration of either 80% (v/v) ethanol or 6% (v/v) acetic acid. Control rats received saline or anti-ulcer drug omeprazole (20 mg/kg) prior to ulcer induction. Results: The extract inhibited the mean lesion score of acetic acid, 4.333 to 3.000. Whereas, for ethanol induced ulcers, the extract reduced the lesion scoring from 2.833 to 1.677. However, this activity was statistically less potent than the anti-ulcer drug, omeprazole. Spirulina platensis alone did not induce any ulcers in rats. Conclusions: These results suggested that Spirulina platensis has gastroprotective activity against ulcers induced by acetic acid and ethanol.Keywords
Gastroprotective, Spirulina platensis, Ethanol, Acetic Acid, Gastric Ulcers- Anti-inflammatory and Anti-nociceptive Activities of the Ethanolic Extract of Annona muricata Leaf
Abstract Views :515 |
PDF Views:424