The Effectiveness of Garcinia Mangostana L. Rind extract in Reducing Total Cholesterol Levels in Hypercholesterolemic Male White Mice

Hypercholesterolemia contributes to the incidence of coronary heart disease which is the leading cause of death in the world¹. Diet modification and hypolipidemic drugs, including herba, one of which is Garcinia mangostana L. will effectively reduce total cholesterol³. A research a posttest control group design²⁰, type of research was a laboratory experimental research¹⁵. The population was male white mice aged 3 - 4 weeks weighing 100-200 grams¹². Hypercholesterolemia in male white rats was with MDLT induction (high - fat diet food)⁷. Data collection of total cholesterol levels measurement used enzymatic spectrophotometer method, data analysis used Variant Analysis statistical test (ANOVA) with significance level α < 0.05 15. The effect of Garcinia mangostana L. rind extract on total cholesterol reduction in white rats was grouped into a negative control group, positive control group and four dose treatment groups⁴. Identification of hypercholesterolaemia in white rats was examined for total cholesterol on day^8,16. The effect of Garcinia Mangostana L rind extract on reducing total cholesterol was examined on day^22,3,16. The results of the examination showed the administration of Garcinia mangostana L. rind extract in all dosage groups effectively reduced total cholesterol levels with a significance level of p < 0.05.