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Patterns of Haemoglobinopathies Diagnosed by High Performance Liquid Chromatography in Karbala Population and Correlations between Different Hematological Parameters


Affiliations
1 FIBMS, Lecturer of Hematopathology, Department of Pathology, College of Medicine, University of Karbala, Karbala, Iraq
2 Hematopathologist, working in Teaching Laboratories, Al-Husseini Teaching Hospital, Karbala, Iraq
3 FIBMS, Lecturer of Histopathology, Department of Pathology, College of Medicine, University of Karbala, Karbala, Iraq
     

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Aim: To know the patterns of hemoglobinopathies and their prevalence in Kerbala society by using high performance liquid chromatography and to conclude if there is any correlations between different hematological parameters in Hemoglobinopathic patients. A total of 70 cases studied from 16th of February 2018 to 20th of June 2018 for hemoglobin variant analysis at the teaching labrotarioes of Al- Hussseini Teaching hospital which were studied for patterns of hemoglobinopathies. When the samples were received, Complete Blood Counts including: Hemoglobin concentration, Total White blood cells count (WBC), Mean Cell Volume (MCV), Mean Cell Haemoglobin (MCH), Mean Cell Hemoglobin Concentration (MCHC), Serum ferritin, Total Iron Binding Capacity ( TIBC), Hemoglobin H (HbH) preparation were done. Out of total 70 patients screened for patterns of hemoglobinopathies the result of the study revealed that 48 Patients which represent(68.57 %) of total patients had B-thalassemia trait which form the predominant percentage of patients with haemoglobinopathy, 11.85% of patients had sickle cell trait, 5.71% of them had B-Thalassemia Major, 4.29% had Hb S/B+Thalassemia Trait, 2.86% had HbS/Alpha thalassemia trait, 1.43% of them had Hb S homozygosity, 1.43% Alpha thalassemia trait, 1.43% had D-Los Anglos, 1.43% had HbS/B+ Thalassemia trait and 1.43% had HbC/B-Thalassemia trait.

Keywords

Hemoglobinopathies, Hb electrophoresis, Hemoglobin Variants, retention time, hemoglobin A2
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  • Patterns of Haemoglobinopathies Diagnosed by High Performance Liquid Chromatography in Karbala Population and Correlations between Different Hematological Parameters

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Authors

Enass Abdul Kareem Al-Saadi
FIBMS, Lecturer of Hematopathology, Department of Pathology, College of Medicine, University of Karbala, Karbala, Iraq
Duha Maithem Hassan
Hematopathologist, working in Teaching Laboratories, Al-Husseini Teaching Hospital, Karbala, Iraq
Wafaa Redha Al-Sabbagh
FIBMS, Lecturer of Histopathology, Department of Pathology, College of Medicine, University of Karbala, Karbala, Iraq

Abstract


Aim: To know the patterns of hemoglobinopathies and their prevalence in Kerbala society by using high performance liquid chromatography and to conclude if there is any correlations between different hematological parameters in Hemoglobinopathic patients. A total of 70 cases studied from 16th of February 2018 to 20th of June 2018 for hemoglobin variant analysis at the teaching labrotarioes of Al- Hussseini Teaching hospital which were studied for patterns of hemoglobinopathies. When the samples were received, Complete Blood Counts including: Hemoglobin concentration, Total White blood cells count (WBC), Mean Cell Volume (MCV), Mean Cell Haemoglobin (MCH), Mean Cell Hemoglobin Concentration (MCHC), Serum ferritin, Total Iron Binding Capacity ( TIBC), Hemoglobin H (HbH) preparation were done. Out of total 70 patients screened for patterns of hemoglobinopathies the result of the study revealed that 48 Patients which represent(68.57 %) of total patients had B-thalassemia trait which form the predominant percentage of patients with haemoglobinopathy, 11.85% of patients had sickle cell trait, 5.71% of them had B-Thalassemia Major, 4.29% had Hb S/B+Thalassemia Trait, 2.86% had HbS/Alpha thalassemia trait, 1.43% of them had Hb S homozygosity, 1.43% Alpha thalassemia trait, 1.43% had D-Los Anglos, 1.43% had HbS/B+ Thalassemia trait and 1.43% had HbC/B-Thalassemia trait.

Keywords


Hemoglobinopathies, Hb electrophoresis, Hemoglobin Variants, retention time, hemoglobin A2



DOI: https://doi.org/10.37506/v20%2Fi1%2F2020%2Fmlu%2F194416