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Zinc Deficiency is Associated with Meprin a in Iraqi Patients with Crohn’s Disease


Affiliations
1 Department of Chemistry, College of Science, Mosul University, Iraq
2 Department of Chemistry, College of Science, AL Mustasiyriah University, Iraq
3 Chemistry and Biochemistry, College of Medicine, AL Mustasiyriah University, Iraq
     

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Zinc deficiency in Crohn’s disease (CD)is considered a frequent finding and may exacerbate CD activity. We aimed to assess the prevalence of zinc deficiency in CD patients in clinical remission, its association with meprin and to analyze a potential impact on future disease course. Proper history with blood samples were collected from (30) healthy control group, (30) Crohn’s disease patients have been respond to biological therapy ( infliximab IFX) (response group) and (30) CD patients with (non-response group) to biological therapy undergoing surgical intervention for the estimation of zinc concentration and meprin activity. This study demonstrate a significant decrease in both zinc and meprin levels between (non- response group) and control group (p< 0.01). Similarly , zinc and meprin levels were decreased significantly ( p< 0.01) in (non- response) group as compared with re sponse group. While there were no differences between control and CD patients that have been treated with infliximab only. Meprin α is a zinc metalloproteinase, and therefore a deficiency of zinc may result in a decrease of meprin level or activity. Thus, we should maintain the balance between the meprin α that is affected by the zinc concentration then may affect the Crohn disease.

Keywords

Zinc, Crohn’s disease, Infliximab, meprin α
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  • Zinc Deficiency is Associated with Meprin a in Iraqi Patients with Crohn’s Disease

Abstract Views: 397  |  PDF Views: 0

Authors

Fatima A. Mohammad
Department of Chemistry, College of Science, Mosul University, Iraq
Fatin Fadhel Alkazazz
Department of Chemistry, College of Science, AL Mustasiyriah University, Iraq
Sura A. Abdlusattar
Chemistry and Biochemistry, College of Medicine, AL Mustasiyriah University, Iraq

Abstract


Zinc deficiency in Crohn’s disease (CD)is considered a frequent finding and may exacerbate CD activity. We aimed to assess the prevalence of zinc deficiency in CD patients in clinical remission, its association with meprin and to analyze a potential impact on future disease course. Proper history with blood samples were collected from (30) healthy control group, (30) Crohn’s disease patients have been respond to biological therapy ( infliximab IFX) (response group) and (30) CD patients with (non-response group) to biological therapy undergoing surgical intervention for the estimation of zinc concentration and meprin activity. This study demonstrate a significant decrease in both zinc and meprin levels between (non- response group) and control group (p< 0.01). Similarly , zinc and meprin levels were decreased significantly ( p< 0.01) in (non- response) group as compared with re sponse group. While there were no differences between control and CD patients that have been treated with infliximab only. Meprin α is a zinc metalloproteinase, and therefore a deficiency of zinc may result in a decrease of meprin level or activity. Thus, we should maintain the balance between the meprin α that is affected by the zinc concentration then may affect the Crohn disease.

Keywords


Zinc, Crohn’s disease, Infliximab, meprin α



DOI: https://doi.org/10.37506/v20%2Fi1%2F2020%2Fmlu%2F194447