Evaluation the Serum Level of Melatonin in Iraqi Patients with Polycystic Ovarian Syndrome

Background: Polycystic Ovarian Syndrome(PCOS) is one of the most frequent gynecological endocrinopathy that occur in premenopausalfemales, with a predominance range from 6%to10% among women of reproductive age. Melatonin (N-acetyl-5-methoxytryptamine), an neurohormone synthesized from the aromatic amino acid tryptophan mainly by the pineal gland of humans.The important of melatonin in human reproduction is still unidentified. A numerous study suggests that melatonin and reproductive hormones are closely related. This concept is based on observation of influence melatonin on sex steroid production at different stages of ovarian follicular maturation as melatonin receptors have been demonstrated at multiple sites in ovary and in intrafollicular fluid. Aim: The study aim to evaluate the role of melatonin in women with polycystic ovarian syndrome. Materials and Methods: A prospective cross-sectional study was designed taking 60 PCOS patients and 30 controls women whose ages were between 15-35 years old, from beginning of January 2019 to ending of April 2019. These patients admitted to obstetrics and gynecology unit at Babylon teaching hospital. And Five ml of blood sample was taken on day 2 of menstrual cycle by vein puncture from each subject enrolled in this study. Blood samples were collected between 07:00 am–8:00 am, and placed into sterile test tubes to serum melatonin estimaResult:tion.  The study showed that there is the significant difference between PCOS women and the control group concerning melatonin level,and the highest mean of melatonin was occurred in PCOS women (61.21 ± 13.78 vs. 28.61 ± 6.73). And also This study showed that there were the higher means of melatonin in PCOS women with positive family history than PCOS women with negative family history (66.56 ± 11.25 vs. 59.26 ± 14.21) with significant relation. Conclusions: Women with PCOS have significant increase of serum melatonin in PCOS women. And also thisstudy could open the way for therapeutic role of melatonin in treatment of PCOS women.