Immunological Role of TLR-7 , IL-17A and IL-10 in a Sample of Iraqi Chronic Renal Failure Patients

Objectives: The present study designed to investigate the Immunological role of toll-like receptor-7, IL-17A and IL-10 in sera of 66 Chronic Renal Failure CRF patients at IBN-SINA center for Dialysis in Diyala governorate - Iraq. Methods: Sandwich Enzyme Linked Immuno-Sorbent Assay(ELISA) technique were used in this study to evaluate concentration of TLR-7 ,IL-17A and IL-10 between study groups. Results: The findings of the present study demonstrated that significantly increased level of TLR-7 in the CRF group (0.24± 0.05 ng/ml) compared to controls (0.02± 0.08 ng/ml), the findings revealed a significant association between CRF and IL-17A serum level in the studied groups,There was a significantly increased level of IL- 17A in the CRF group (6.50±1.37 pg/ml) compared to controls (2.19± 0.32 pg/ml) also decreased level of IL-10 in the CRF group (26.20± 5.16 pg/ml) compared to controls (79.27±23.44 pg/ml). Conclusion: These findings concluded that TLR-7, IL-17A and IL-10 might have a role in CRF pathogenesis.