Serum Salusin-α and Salusin -b levels with some Biochemical Parameters in Patients with Major Thalassemia

Thalassemias are a heterogeneous group of genetic disorders in which the production of normal hemoglobin partially or completely is suppressed because of defective synthesis of one or more globin chain. It is sometimes called Mediterranean anemia. Many biochemical changes in the blood accompany this disease. In this research, some biochemical parameters were measured in thalassemic patients and compared with healthy control group. These parameters include serum Iron, ferritin , TIBC, transferrin, transferrin saturation percentage, Salusin-α , salusin-β, insulin ,and lipid profile. The aim of this study was to Measuring the level of cytokine(salusin- α and salusin -b ) lipid profile, blood sugar level and resistance to insulin in serum of thalassemia patients and Find interconnectivity between cytokine(salusin- α and salusin -b ), iron , lipid profile, blood sugar level and insulin resistance. The results of the research showed that there is a significant increase (P<0.05) in BMI,serum iron, ferritin ,UIBC, TS%,FBG, Insulin , HOMA-β, TG, cholesterol, HDL-C, LDL-C, and salusin -b in thalassemic patients group in comparison with healthy control group. A significant decrease (P<0.05) in HOMA-IR and salusin- α . There is no significant difference (P>0.05) in Age,TIBC,Transferrin, and VLDL-C.