Research Journal of Pharmacy and Technology

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Phytochemical Investigation of Trichosanthes cucumerina linn for Analgesic Activity


Affiliations
1 Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram-600117, Tamilnandu, India
     

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Trichosanthes cucumerina linn is used as a traditional medicine for various diseases. In the present study was conducted to evaluate theanalgesic activity for Petroleum ether and Methanol extract of Trichosanthes cucumerinalinn and the activity was compared with diclofenac sodium as a standardand assessed using acetic acid induced abdominal writhing in mice.The methanolic extract exhibited significant value (P<0.001)analgesic activity as evidenced by increased the percentage of reduction in reaction time. The results thus support the Trichosanthes cucumerina linn used as ananalgesic agent. The plant showed no sign of toxicityup to the dose of 100 mg/kg in mice.

Keywords

Trichosanthes cucumerina linn, Analgesic Activity, Phytochemical Screening, Structural Elucidation, IR.
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  • Phytochemical Investigation of Trichosanthes cucumerina linn for Analgesic Activity

Abstract Views: 224  |  PDF Views: 3

Authors

Mohamed Zerein Fathima
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram-600117, Tamilnandu, India
T. S. Shanmugarajan
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram-600117, Tamilnandu, India
I. Somasundharam
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram-600117, Tamilnandu, India
J. Anisha Ebens
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram-600117, Tamilnandu, India
T. T. Neethu
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram-600117, Tamilnandu, India

Abstract


Trichosanthes cucumerina linn is used as a traditional medicine for various diseases. In the present study was conducted to evaluate theanalgesic activity for Petroleum ether and Methanol extract of Trichosanthes cucumerinalinn and the activity was compared with diclofenac sodium as a standardand assessed using acetic acid induced abdominal writhing in mice.The methanolic extract exhibited significant value (P<0.001)analgesic activity as evidenced by increased the percentage of reduction in reaction time. The results thus support the Trichosanthes cucumerina linn used as ananalgesic agent. The plant showed no sign of toxicityup to the dose of 100 mg/kg in mice.

Keywords


Trichosanthes cucumerina linn, Analgesic Activity, Phytochemical Screening, Structural Elucidation, IR.