Bronchodilator and Mast Cell Stabilizer Effect of Siddha Formulation Seenthil Chooranam

The present study aimed to evaluate anti-asthmatic activity of a classical Siddha formulation Seenthil chooranam (SC) by mast cell stabilizing effect and broncho dilator property by in-vivo method. Preliminary phytochemical and HPTLC analysis of SC were determined as per standard protocols. Phytochemical analysis of aqueous extract gave positive test for carbohydrates, phenols, glycosides, saponins, flavonoids, tannins and terpenoids. HPTLC finger print analysis of the aqueous extract showed the presence of possible number of components. The results of the in-vivo study demonstrate that SC has potent broncho dilator property with significant (p<0.001) mast cell stabilizing activity and decrease in leukocytosis in dose dependent manner. These findings are clearly indicative of the role of SC as potent inhibitor of mast cell degranulation and ability to control the leukocytosis, have bronchodilation and hence can be used for the management of asthma supporting the traditional claims.