A Complexity Focus on Nanotoxicology-A Review

This article will discuss some of the general considerations on the complexity of Nanotoxicology (NT). The real scope of Nanotoxicology involves many processes. Nanotoxicology is an emerging discipline evolving from studies of ultrafine particles called the nano-particles (NP). The small size facilitates uptake into cells and transcytosis across epithelial and endothelial cells into the blood and lymph circulation to reach potentially sensitive target sites such as bone marrow, lymph nodes, spleen, and heart. Access to the central nervous system (CNS) and ganglia via translocation along axons and dendrites of neurons, evidences of mitochondrial distribution and oxidative stress response after NSP endocytosis point to a need for basic research on their interactions with subcellular structures.