Research Journal of Pharmacy and Technology

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Anti-Proliferative Activity of Chlorophyllin from Phyllanthus emblica L. Against MCF-7 and Vero Cell Line


Affiliations
1 Department of Biotechnology, Mohamed Sathak College of Arts and Science, Sholinganallur, Chennai- 119, India
2 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Pallavaram, Chennai, India
     

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Chlorophyllin refers to any one of a group of closely related water-soluble salts that are semi-synthetic derivatives of chlorophyll. It is most common form is sodium copper derivative used as a food additive and in alternative medicine. In this study sodium copper chlorophyllin was extracted from Phyllanthus emblica, a medicinal plant and estimated by visible spectrophotometer and further characterized by TLC, IR, NMR and GC-Mass Chromatographic techniques and studied the anticancer activity against MCF-7 cell line and Vero cell line. Result shows that Chlorophyllin of Phyllanthus emblica has good anticancer activity for breast cancer cell line by using MTT assay.

Keywords

Chlorophyllin, Thin Layer Chromatography, MTT Assay.
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  • Anti-Proliferative Activity of Chlorophyllin from Phyllanthus emblica L. Against MCF-7 and Vero Cell Line

Abstract Views: 230  |  PDF Views: 1

Authors

M. Durga Devi
Department of Biotechnology, Mohamed Sathak College of Arts and Science, Sholinganallur, Chennai- 119, India
N. Banu
Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Pallavaram, Chennai, India

Abstract


Chlorophyllin refers to any one of a group of closely related water-soluble salts that are semi-synthetic derivatives of chlorophyll. It is most common form is sodium copper derivative used as a food additive and in alternative medicine. In this study sodium copper chlorophyllin was extracted from Phyllanthus emblica, a medicinal plant and estimated by visible spectrophotometer and further characterized by TLC, IR, NMR and GC-Mass Chromatographic techniques and studied the anticancer activity against MCF-7 cell line and Vero cell line. Result shows that Chlorophyllin of Phyllanthus emblica has good anticancer activity for breast cancer cell line by using MTT assay.

Keywords


Chlorophyllin, Thin Layer Chromatography, MTT Assay.