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Development of Naratriptan Hydrochloride In-Situ Nasal Gel


Affiliations
1 Department of Quality Assurance Techniques, KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
2 Department of Pharmaceutics , KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
3 Department of Pharmaceutical Chemistry, KCT’S, Ravindra Gambhirrao College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
     

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Development of pH sensitive Naratriptan Hydrochloride in-situ nasal gel was aimed to improve absorption. In the present research work mixture of Carbopol-934 and Xanthan Gum were used to benefit pH sensitive gelation property. Different formulation were prepared by different concentrations of Carbopol-934 and Xanthan Gum .In this formulation the release profile depend on the concentration of Carbopol-934 and Xanthan Gum. These formulations were evaluated for parameters like pH, drug content, viscosity, mucoadhesive strength, gel strength, in-vitro drug release, and drug and excipients compatability. A 32 factorial design was applied to see the effect of various Carbopol-934 (X1) and Xanthan gum (X2) on the various models to a certain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The study indicates that the formulation was effective in providing in-vitro release of drug and the mucoadhesive formulation. The objective of this study was to formulate a intranasal gel for drug targeting directly to brain via olfactory lobe pathway.

Keywords

Anti-Migraine, Carbopol-934, Xanthan Gum, In-Situ Gelling System, pH Sensitive.
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  • Development of Naratriptan Hydrochloride In-Situ Nasal Gel

Abstract Views: 267  |  PDF Views: 3

Authors

Nikita S. Malekar
Department of Quality Assurance Techniques, KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
Sheetal B. Gondkar
Department of Quality Assurance Techniques, KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
Bhushan A. Bhairav
Department of Quality Assurance Techniques, KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
Pinak S. Paralkar
Department of Pharmaceutics , KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India
Ravindra B. Saudagar
Department of Pharmaceutical Chemistry, KCT’S, Ravindra Gambhirrao College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, India

Abstract


Development of pH sensitive Naratriptan Hydrochloride in-situ nasal gel was aimed to improve absorption. In the present research work mixture of Carbopol-934 and Xanthan Gum were used to benefit pH sensitive gelation property. Different formulation were prepared by different concentrations of Carbopol-934 and Xanthan Gum .In this formulation the release profile depend on the concentration of Carbopol-934 and Xanthan Gum. These formulations were evaluated for parameters like pH, drug content, viscosity, mucoadhesive strength, gel strength, in-vitro drug release, and drug and excipients compatability. A 32 factorial design was applied to see the effect of various Carbopol-934 (X1) and Xanthan gum (X2) on the various models to a certain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The study indicates that the formulation was effective in providing in-vitro release of drug and the mucoadhesive formulation. The objective of this study was to formulate a intranasal gel for drug targeting directly to brain via olfactory lobe pathway.

Keywords


Anti-Migraine, Carbopol-934, Xanthan Gum, In-Situ Gelling System, pH Sensitive.