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Development of Naratriptan Hydrochloride In-Situ Nasal Gel
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Development of pH sensitive Naratriptan Hydrochloride in-situ nasal gel was aimed to improve absorption. In the present research work mixture of Carbopol-934 and Xanthan Gum were used to benefit pH sensitive gelation property. Different formulation were prepared by different concentrations of Carbopol-934 and Xanthan Gum .In this formulation the release profile depend on the concentration of Carbopol-934 and Xanthan Gum. These formulations were evaluated for parameters like pH, drug content, viscosity, mucoadhesive strength, gel strength, in-vitro drug release, and drug and excipients compatability. A 32 factorial design was applied to see the effect of various Carbopol-934 (X1) and Xanthan gum (X2) on the various models to a certain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The study indicates that the formulation was effective in providing in-vitro release of drug and the mucoadhesive formulation. The objective of this study was to formulate a intranasal gel for drug targeting directly to brain via olfactory lobe pathway.
Keywords
Anti-Migraine, Carbopol-934, Xanthan Gum, In-Situ Gelling System, pH Sensitive.
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