Evaluation of Antipsychotic Effect of Levosulpride

The present study was undertaken to evaluate the antipsychotic activity of formulated levosulpride sustained release formulation was compared with marketed levosulpride sustained release formulation in experimental animal models. Male Wistar rats (180- 220 g) and Albino mice (25-30 g) were used for the study. The antipsychotic effect of the formulated levosulpride sustained release formulation was evaluated on locomotor activity on photoactometer and ketamine induced stereotypic behavior. Different groups of rats were fed orally with a specially prepared diet containing formulated levosulpride sustained release formulation was compared with marketed levosulpride sustained release formulation for 15 consecutive days. Further, the biochemical estimations were done by estimating brain dopamine levels. The formulated levosulpride sustained release formulation significantly decreased the locomotor activity of rats. The formulated levosulpride sustained release formulation significantly decreased ketamine (50 mg/kg, i.p.) induced stereotyped behavior in a dose dependent manner. Formulated levosulpride sustained release formulation significantly decreased the brain dopamine levels. The results suggest that formulated levosulpride sustained release formulation posse's antipsychotic activity.