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Synthesis, Biological and Pharmacological Screening of Novel Pyrimidine Derivatives
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A series of novel 4-(4-nitrophenyl)-6-phenyl substituted pyrimidine-2-thiol (PM1-PM6) have been synthesized by refluxing 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one in presence of thiourea and glacial acetic acid. 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one were prepared by condensing 4-nitroacetophenone with substituted benzaldehydes in presence of 20% NaOH as base. The structures of newly synthesized compounds were characterized by IR, 1H NMR and mass spectroscopic studies. Newly synthesized compounds were screened for their anti-inflammatory and cytotoxic studies. Few of the compounds exhibited excellent anti-inflammatory compared to the standard drug diclofenac sodium. Some compounds have shown moderate cytotoxic activities.
Keywords
Chalcones, Pyrimidine, Cytotoxic Activity, Anti-Inflammatory Activity.
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