Research Journal of Pharmacy and Technology

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Synthesis and Physico Chemical Studies of Some Chalcone and Their Derivatives as Potential Antimicrobial Agents


Affiliations
1 School of Applied Sciences, Singhania University, Pacheri Bari, Jhunjhunu (Raj.), India
2 Department of Chemistry, Agra College, Agra, U.P, India
     

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The Chalcone is an aromatic compound that forms the central core for various necessities of biological compounds. The Chalcone is synthesized by Claisen - Schmidt condensation of benzaldehyde derivatives with acetophenone derivatives in dilute ethanolic sodium hydroxide solution at room temperature. The structures of synthesized compounds were investigated by IR Spectroscopy, NMR Spectroscopy and Mass Spectrometry. The antimicrobial activity of the synthesized was evaluated by Filter Paper Disc diffusion Method. The compound 1b showed excellent activity against S. aureus at both concentration i.e. 500μg/ml and1000 μg/ml.

Keywords

Chalcone Derivates, Antimicrobial Agents.
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  • Synthesis and Physico Chemical Studies of Some Chalcone and Their Derivatives as Potential Antimicrobial Agents

Abstract Views: 173  |  PDF Views: 3

Authors

Arun Kumar
School of Applied Sciences, Singhania University, Pacheri Bari, Jhunjhunu (Raj.), India
Vinita Gupta
Department of Chemistry, Agra College, Agra, U.P, India
Sanchita Singh
Department of Chemistry, Agra College, Agra, U.P, India
Y. K. Gupta
Department of Chemistry, Agra College, Agra, U.P, India

Abstract


The Chalcone is an aromatic compound that forms the central core for various necessities of biological compounds. The Chalcone is synthesized by Claisen - Schmidt condensation of benzaldehyde derivatives with acetophenone derivatives in dilute ethanolic sodium hydroxide solution at room temperature. The structures of synthesized compounds were investigated by IR Spectroscopy, NMR Spectroscopy and Mass Spectrometry. The antimicrobial activity of the synthesized was evaluated by Filter Paper Disc diffusion Method. The compound 1b showed excellent activity against S. aureus at both concentration i.e. 500μg/ml and1000 μg/ml.

Keywords


Chalcone Derivates, Antimicrobial Agents.