Research Journal of Pharmacy and Technology

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Synthesis and Characterization of Indolyl-Pyrazoline and their Evaluation of Anti-inflammatory Activity


Affiliations
1 Deptt. of Pharmaceutical Sciences, Uttarakhand Technical University, Deheradun, United Kingdom
2 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), India
3 Shri Shankaracharya Institute of Pharmaceutical Sciences, Bhilai (C.G.), India
     

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In the present work, ten novel 3-(4,5-dihydro-3-(naphthalen-1-yl)- N1-substituted -pyrazol-5-yl)-1H-indole [1,1a,1b.1e,2] and 3-(4,5-dihydro-3-(pyridin-3-yl)-N1-substituted-pyrazol-5-yl)-1H-indole [5,5a,5b,5e.6] were synthesized by condensation between substituted pyrazoline and substituted hydrazine in the presence of glacial acetic acid. The synthesized compounds were evaluated for their anti-inflammatory activity using carrageenaninduced paw oedema method and compared to the well known NSAID indomethacin as a standard drug. The entire synthesized compounds were characterized by elemental analysis, IR, 1H NMR and mass spectroscopy.

Keywords

Anti-Inflammatory Activity, Carageenan Induced Paw Oedema Method, Indole, Pyrazoline, Indolyl Pyrazoline.
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  • Synthesis and Characterization of Indolyl-Pyrazoline and their Evaluation of Anti-inflammatory Activity

Abstract Views: 211  |  PDF Views: 3

Authors

Minakshi Shroff
Deptt. of Pharmaceutical Sciences, Uttarakhand Technical University, Deheradun, United Kingdom
S. J. Daharwal
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), India
Yashwant Swarnakar
Shri Shankaracharya Institute of Pharmaceutical Sciences, Bhilai (C.G.), India

Abstract


In the present work, ten novel 3-(4,5-dihydro-3-(naphthalen-1-yl)- N1-substituted -pyrazol-5-yl)-1H-indole [1,1a,1b.1e,2] and 3-(4,5-dihydro-3-(pyridin-3-yl)-N1-substituted-pyrazol-5-yl)-1H-indole [5,5a,5b,5e.6] were synthesized by condensation between substituted pyrazoline and substituted hydrazine in the presence of glacial acetic acid. The synthesized compounds were evaluated for their anti-inflammatory activity using carrageenaninduced paw oedema method and compared to the well known NSAID indomethacin as a standard drug. The entire synthesized compounds were characterized by elemental analysis, IR, 1H NMR and mass spectroscopy.

Keywords


Anti-Inflammatory Activity, Carageenan Induced Paw Oedema Method, Indole, Pyrazoline, Indolyl Pyrazoline.