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Dynamic Changes of the Microflora Sensitivity to Antibiotics in Patients with Chronic Calculous Pyelonephritis


Affiliations
1 Federal State Budgetary Institution of Higher Professional Education “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, Russian Federation
2 Department of Urology of Non-Governmental Healthcare Institution of Regional Clinical Hospital at the Station Volgograd-1, JSC "Russian Railways", Avtotransportnaya Street, 75, Volgograd, 400131, Russian Federation
     

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Secondary pyelonephritis occurs in 48.3% - 89.3% of cases and complicates the states of the disease. The effectiveness of therapy and prognosis of the disease depends on chosen methods of antibiotic prophylaxis of pyoinflammatory kidney diseases. The purpose of the research: To improve the results of patients' treatment with complicated calculous pyelonephritis. Materials and methods: We have examined 179 people. This was a retrospective pharmacoepidemiological analysis of medical documents of patients, treated in 2009 and in 2013 in a hospital of Volgograd. The number of women, taking part in the research was 99 (55.4%) and men - 80 (44%). All patients underwent a standard clinical examination, with the mandatory bacteriological urinalysis, renal ultrasound. Results: Among patients with chronic calculous pyelonephritis, the most common infectious agents are the following: E.coli - 72,4%, Staph. epidermidis - 20,8%, P. aeruginosa - 26,8%. The greatest sensitivity to infectious agents possess the next preparations: carbopenems (meronems) - 92%, amoxicillin + clavulanic acid - 86.4%, cefotaxime - 89.4%. The greatest resistance of E.Coli is to ciprofloxacin and ampicillin. Conclusions: The regular review of recommendations for antimicrobial therapy of urinary tract infections is necessary, due to the constant changes in the level of uropathogens resistance.

Keywords

Urolithiasis, Calculous Pyelonephritis, Antibiotic Sensitivity.
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  • Dynamic Changes of the Microflora Sensitivity to Antibiotics in Patients with Chronic Calculous Pyelonephritis

Abstract Views: 185  |  PDF Views: 1

Authors

N. G. Kulchenko
Federal State Budgetary Institution of Higher Professional Education “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, Russian Federation
S. M. Chibisov
Federal State Budgetary Institution of Higher Professional Education “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, Russian Federation
I. Z. Eremina
Federal State Budgetary Institution of Higher Professional Education “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, Russian Federation
M. A. Vekilyan
Department of Urology of Non-Governmental Healthcare Institution of Regional Clinical Hospital at the Station Volgograd-1, JSC "Russian Railways", Avtotransportnaya Street, 75, Volgograd, 400131, Russian Federation
S. P. Syatkin
Federal State Budgetary Institution of Higher Professional Education “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, Russian Federation
A. S. Skorik
Federal State Budgetary Institution of Higher Professional Education “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, Russian Federation
G. I. Myandina
Federal State Budgetary Institution of Higher Professional Education “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, Russian Federation
N. A. Shevkun
Federal State Budgetary Institution of Higher Professional Education “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, Russian Federation
E. V. Neborak
Federal State Budgetary Institution of Higher Professional Education “People’s Friendship University of Russia”, Mikloukho-Macklay Street, 6, Moscow, 117198, Russian Federation

Abstract


Secondary pyelonephritis occurs in 48.3% - 89.3% of cases and complicates the states of the disease. The effectiveness of therapy and prognosis of the disease depends on chosen methods of antibiotic prophylaxis of pyoinflammatory kidney diseases. The purpose of the research: To improve the results of patients' treatment with complicated calculous pyelonephritis. Materials and methods: We have examined 179 people. This was a retrospective pharmacoepidemiological analysis of medical documents of patients, treated in 2009 and in 2013 in a hospital of Volgograd. The number of women, taking part in the research was 99 (55.4%) and men - 80 (44%). All patients underwent a standard clinical examination, with the mandatory bacteriological urinalysis, renal ultrasound. Results: Among patients with chronic calculous pyelonephritis, the most common infectious agents are the following: E.coli - 72,4%, Staph. epidermidis - 20,8%, P. aeruginosa - 26,8%. The greatest sensitivity to infectious agents possess the next preparations: carbopenems (meronems) - 92%, amoxicillin + clavulanic acid - 86.4%, cefotaxime - 89.4%. The greatest resistance of E.Coli is to ciprofloxacin and ampicillin. Conclusions: The regular review of recommendations for antimicrobial therapy of urinary tract infections is necessary, due to the constant changes in the level of uropathogens resistance.

Keywords


Urolithiasis, Calculous Pyelonephritis, Antibiotic Sensitivity.