Research Journal of Pharmacy and Technology

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Epigallocatechin Gallate Attenuates Behavioral Defects in Sodium Valproate Induced Autism Rat Model


Affiliations
1 Department of Biotechnology, St. Joseph’s College (Autonomous), Tiruchirappalli, Tamil Nadu, India
2 Department of Botany, St. Joseph’s College (Autonomous), Tiruchirappalli, Tamil Nadu, India
3 Department of Biochemistry and Biotechnology, Annamalai University, Chidambaram, Tamil Nadu, India
     

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Pregnant rats were administered by either sodium valproate (VPA) with 250 mg/kg during fetal neural tube development on embryonic day 12, induces neural tube defects and impairment in behaviors related to autistic spectrum disorder in newborns, which make it a useful animal model of autism. Male rat pups were subjected to behavioral testing to assess exploratory activity, peripheral and central movements and motor activity like grooming and rearing on postnatal day 90. We investigated the role of EGCG (2mg/kg) in reversing cardinal behavioral changes induced by VPA exposed rats. Consumption of EGCG has been associated with neuronal protection against the impact of toxicants. EGCG exerts neuronal cytoprotective action possibly due to antioxidant action and neuroprotective effect could be efficacious in the management of autism.

Keywords

Autism, VPA, EGCG, Behavior.
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  • Epigallocatechin Gallate Attenuates Behavioral Defects in Sodium Valproate Induced Autism Rat Model

Abstract Views: 246  |  PDF Views: 3

Authors

P. Kumaravel
Department of Biotechnology, St. Joseph’s College (Autonomous), Tiruchirappalli, Tamil Nadu, India
G. Melchias
Department of Botany, St. Joseph’s College (Autonomous), Tiruchirappalli, Tamil Nadu, India
N. Vasanth
Department of Botany, St. Joseph’s College (Autonomous), Tiruchirappalli, Tamil Nadu, India
T. Manivasagam
Department of Biochemistry and Biotechnology, Annamalai University, Chidambaram, Tamil Nadu, India

Abstract


Pregnant rats were administered by either sodium valproate (VPA) with 250 mg/kg during fetal neural tube development on embryonic day 12, induces neural tube defects and impairment in behaviors related to autistic spectrum disorder in newborns, which make it a useful animal model of autism. Male rat pups were subjected to behavioral testing to assess exploratory activity, peripheral and central movements and motor activity like grooming and rearing on postnatal day 90. We investigated the role of EGCG (2mg/kg) in reversing cardinal behavioral changes induced by VPA exposed rats. Consumption of EGCG has been associated with neuronal protection against the impact of toxicants. EGCG exerts neuronal cytoprotective action possibly due to antioxidant action and neuroprotective effect could be efficacious in the management of autism.

Keywords


Autism, VPA, EGCG, Behavior.