Synthesis, Antibacterial and Antifungal Evaluation of Novel Pyrazoline Derivatives

A novel series of Chalcones (2a-j) were prepared by reacting Furfuraldehyde and substituted ketones in alcohol medium in presence of NaOH. The Chalcones undergoes selective cyclization with Benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1,3,5-trisubstituted Pyrazolines (3a-j). All the newly synthesized compounds were evaluated for their In-Vitro antibacterial and antifungal activities. The new compounds were assigned on the basis of ¹H-NMR, IR, Mass spectral data and elemental analysis. Some of the tested compounds showed potent activity against antifungal organism A.fumigatus.