Research Journal of Pharmacy and Technology

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Chemo Preventive Activity of Triumfetta rhomboidea in 7, 12-Dimethylbenz (A) Anthracene Induced Breast Cancer in Sprague–Dawley Rat Model


Affiliations
1 Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, India
2 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, India
3 Department of Pharmaceutics, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, India
     

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The chemopreventive potential was assessed by monitoring the tumour incidence, total no of tumours and tumour volume and also by analyzing the level of biochemical markers such as 17-β estradiol (E2), TBARS and antioxidants during DMBA induced mammary carcinoma. A single subcutaneous injection of DMBA (25mg/kg) produced mammary carcinoma in female Sprague-Dawley rats. Oral administration of 100mg/kg and 200mg/kg of TRM to DMBA treated rats significantly prevented the tumour incidence, total no of tumours, tumour volume and brought back the above said biochemical markers to normal. The present study confirmed the chemopreventive activity of leaves of Triumfetta rhomboidea in mammary carcinoma

Keywords

Mammary Carcinoma, Triumfetta rhomboidea, Leaves, DMBA, Antioxidants.
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  • Chemo Preventive Activity of Triumfetta rhomboidea in 7, 12-Dimethylbenz (A) Anthracene Induced Breast Cancer in Sprague–Dawley Rat Model

Abstract Views: 224  |  PDF Views: 1

Authors

R. Suresh
Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, India
D. Benitojohnson
Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, India
C. Maheswari
Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, India
R. Venkatnarayanan
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, India
R. Manavalan
Department of Pharmaceutics, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, India

Abstract


The chemopreventive potential was assessed by monitoring the tumour incidence, total no of tumours and tumour volume and also by analyzing the level of biochemical markers such as 17-β estradiol (E2), TBARS and antioxidants during DMBA induced mammary carcinoma. A single subcutaneous injection of DMBA (25mg/kg) produced mammary carcinoma in female Sprague-Dawley rats. Oral administration of 100mg/kg and 200mg/kg of TRM to DMBA treated rats significantly prevented the tumour incidence, total no of tumours, tumour volume and brought back the above said biochemical markers to normal. The present study confirmed the chemopreventive activity of leaves of Triumfetta rhomboidea in mammary carcinoma

Keywords


Mammary Carcinoma, Triumfetta rhomboidea, Leaves, DMBA, Antioxidants.