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Formulation and Evaluation of Orodispersible Tablets of an Antiulcer Agent


Affiliations
1 Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, Rajahmundry, Andhra Pradesh-533102, India
2 Department of Pharmaceutics, N G S M Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka – 575 018, India
     

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In the present work, an attempt has been made to formulate oral dispersible tablets of omeprazole by three different methods. Conventional tabletting procedure was followed for the preparation of tablets. Three batches omeprazole were prepared and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release, kinetics and stability studies. Formulations prepared by omeprazole superdisintegrants addition method emerged as the best formulations, as they showed rapid in vitro disintegration time, in vitro dispersion time and drug release at the end of 5 min, apart from taste and excellent mouth feel compared to other methods. It was concluded that oral dispersible tablets of anti ulcer agents can be successfully formulated and will be used as a novel drug dosage form for pediatrics and geriatrics with improved patient compliance.

Keywords

Omeprazole, Orodispersible Tablets, Superdisintegrants.
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  • Formulation and Evaluation of Orodispersible Tablets of an Antiulcer Agent

Abstract Views: 181  |  PDF Views: 1

Authors

D. Srinivasa Sastry
Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, Rajahmundry, Andhra Pradesh-533102, India
R. Narayana Charyulu
Department of Pharmaceutics, N G S M Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka – 575 018, India
D. S. Satyanarayana
Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, Rajahmundry, Andhra Pradesh-533102, India
D. Srilakshmi
Department of Pharmaceutics, Aditya College of Pharmacy, Surampalem, Rajahmundry, Andhra Pradesh-533102, India

Abstract


In the present work, an attempt has been made to formulate oral dispersible tablets of omeprazole by three different methods. Conventional tabletting procedure was followed for the preparation of tablets. Three batches omeprazole were prepared and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release, kinetics and stability studies. Formulations prepared by omeprazole superdisintegrants addition method emerged as the best formulations, as they showed rapid in vitro disintegration time, in vitro dispersion time and drug release at the end of 5 min, apart from taste and excellent mouth feel compared to other methods. It was concluded that oral dispersible tablets of anti ulcer agents can be successfully formulated and will be used as a novel drug dosage form for pediatrics and geriatrics with improved patient compliance.

Keywords


Omeprazole, Orodispersible Tablets, Superdisintegrants.