Research Journal of Pharmacy and Technology

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Effects of L-lysine-α-Oxidase from Trichoderma In Vitro Experiments on the model of Viruses as Sindbis, Tick-Borne encephalitis, West Nile, Tahyna and Dhori


Affiliations
1 Federal State Budgetary Institution “Research Institute of Epidemiology and Microbiology Named after Honorable Academician N. F. Gamaleya”, 16 Gamalei Str, Moscow, Russian Federation
2 Medical Department of Medical Institute of Peoples’ Friendship University of Russia, 3 Ordzhonikidze Str., Moscow, Russian Federation
     

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For the first time we studied the effect of the anticancer drug L-lysine-α-oxidase, obtained from culture liquid of Trichoderma harzianum Rifai F-180.

In vitro experiments we established the high activity of L-lysine-α-oxidase in a model of tick-borne encephalitis and the lack of activity against viruses Sindbis, West Nile, Tahyna and Dhori.


Keywords

L-lysine-α-Oxidase, Arboviruses, Tick-Borne Encephalitis, Cytopathic Effect, Antiviral Activity.
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  • Effects of L-lysine-α-Oxidase from Trichoderma In Vitro Experiments on the model of Viruses as Sindbis, Tick-Borne encephalitis, West Nile, Tahyna and Dhori

Abstract Views: 240  |  PDF Views: 1

Authors

V. F. Larichev
Federal State Budgetary Institution “Research Institute of Epidemiology and Microbiology Named after Honorable Academician N. F. Gamaleya”, 16 Gamalei Str, Moscow, Russian Federation
I. P. Smirnova
Medical Department of Medical Institute of Peoples’ Friendship University of Russia, 3 Ordzhonikidze Str., Moscow, Russian Federation
S. P. Syatkin
Medical Department of Medical Institute of Peoples’ Friendship University of Russia, 3 Ordzhonikidze Str., Moscow, Russian Federation
G. I. Myandina
Medical Department of Medical Institute of Peoples’ Friendship University of Russia, 3 Ordzhonikidze Str., Moscow, Russian Federation
S. M. Chibisov
Medical Department of Medical Institute of Peoples’ Friendship University of Russia, 3 Ordzhonikidze Str., Moscow, Russian Federation
Е. А. Ryskina
Medical Department of Medical Institute of Peoples’ Friendship University of Russia, 3 Ordzhonikidze Str., Moscow, Russian Federation

Abstract


For the first time we studied the effect of the anticancer drug L-lysine-α-oxidase, obtained from culture liquid of Trichoderma harzianum Rifai F-180.

In vitro experiments we established the high activity of L-lysine-α-oxidase in a model of tick-borne encephalitis and the lack of activity against viruses Sindbis, West Nile, Tahyna and Dhori.


Keywords


L-lysine-α-Oxidase, Arboviruses, Tick-Borne Encephalitis, Cytopathic Effect, Antiviral Activity.