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Investigation of In-Vitro Anthelmintic Activity of Lindernia madayiparense
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Helminthiasis causes a large threatening to the public health and lead to the prevalence of malnutrition, anemia, eosinophilia and pneumonia in developing countries. Due to the high cost of currently available anthelmintic drugs and also the gastro-intestinal helminthes becomes resistant to the drugs; the research on herbal remedies as alternative anthelmintics has been increased. The present study was aimed to assess the anthelmintic activity of the plant, Lindernia madayiparense against Indian earthworms, Pheretima posthuma. Different extracts were prepared using decoction and continuous hot extraction methods. Preliminary qualitative analysis was carried out on all the extracts of L. madayiparanse to identify the presence of phytochemical constituents. Among the extracts tested, ethanol extract showed excellent anthelmintic activity as well as higher than other extracts at all the concentrations against the earth worms and well comparable with standard drug, Albendazole. All the extracts tested exhibited a dose dependent paralytic effect and the time of death. From these findings it was suggested that the observed anthelmintic activity might be due to the presence of these secondary metabolites such as alkaloids, flavanoids, terpenoids, tannins and saponins.
Keywords
Lindernia madayiparense, Anthelmintic, Pheretima posthuma, Dose Dependent, Ethanol Extract.
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- Sangh P, Saurabh K, Amit K, Neeraj KS and Jh KK. In-vitro anthelmintic activity of Luffa cylindrica leaves in Indian adult earthworm. Journal of Pharmacognosy and Phytochemistry. 1(2); 2012: 27-30.
- Yashaswini T, Akshara AM, Krupanidhi, Prasad K, Kumar MD and Akshaykumar K. Anthelmintic activity of seed extracts of Artocarpus heterophyllus. IOSR Journal of Pharmacy and Biological Sciences. 11(5); 2016: 19-23.
- Khan A, Hidayatullah T, Ruqiaya N, Bashir AL and Javaid AP. In-vitro anthelmintic and antimicrobial activities of methanolic extracts of Fumaria indica. Clinical Microbiology. 3(5); 2014: 15.
- Narayanan MKR, Sunil CN, Nandakumar MK, Sujana KA, Jayesh PJ and Anilkumar N. Lindernia madayiparense (Linderniaceae) - A new species from Kerala, India. International Journal of Plant, Animal and Environmental Sciences. 2(3); 2012: 59-62.
- Umakrithika C, Anandarajagopal K and Kannan K. Anti-oxidant activity of Linderina madayiparense extracts. International Journal of ChemTech Research. 10(3); 2017: 178-184.
- Julienne MUPAH, Billy PD and Rio JTD. Anthelmintic efficacy of jackfruit (Artocarpus heterophyllus L.) and tamarind (Tamarindus indica L.) leaves decoction against gastrointestinal nematodes of goats. Philippine Journal of Veterinary and Animal Sciences. 38(2); 2012: 157-166.
- Luciana SS, Larissa B, Paulo CS, Miriam AOP, Leticia, OMD, Camila SMM, Elita S, Rodrigo LF, Helena C and Maria PHA. Preparation of dry extract of Mikania glomerata Sprengel (Guaco) and determination of its coumarin levels by spectrophotometry and HPLC-UV. Molecules. 17; 2012: 1034410354.
- Ben IO, Woode E, Abotsi WKM and Boakye GE. Preliminary phytochemical screening and in-vitro antioxidant properties of Trichilia monadelpha (Thonn.) J. J. de Wilde (Meliaceae). Journal of Biomedical Science. 2(2); 2013: 6-15.
- Benmehdi LH, Hasnaoui O, Benali O and Salhi F. Phytochemical investigation of leaves and fruits extracts of Chamaerops humilis. Journal of Materials and Environmental Science. 3(2); 2012: 320327.
- Deepa N and Ravichandiran V. Antimicrobial activity of extractives of Solidago canadensis L. International Journal of Research in Pharmaceutical Sciences. 1(4); 2010: 411-413.
- Ajaiyeoba EO, Onocha PA and Olarenwaju OT. In-vitro anthelmintic properties of Buchholzia coiaceae and Gynandropsis gynandra extract. Pharmaceutical Biology. 39; 2001: 217–220.
- Krishanu S, Emdad H and Dilip KP. Anthelmintic activity of Hygrophila difformis Blume. Journal of Buffalo Science.1; 2012: 35-38.
- Das SS, Monalisha D and Ghosh AK. Determination of anthelmintic activity of the leaf and bark extract of Tamarindus indica Linn. Indian Journal of Pharmaceutical Sciences. 73(1); 2011: 104–107.
- Kabir MSH, Ahmad S, Mahamoud MS, Masum MAA, Kamal ATMM, Hoque MA and Adnan M. Evaluation of Total condensed tannin content and anthelmintic activities of organic extracts of four Bangladeshi plants on Tubifex tubifex worm using in vitro method. International Journal of Pharmacy. 5(3); 2015: 903-910.
- Shrestha B, Basnett H, Babu VD and Patel SS. Anthelmintic and antimicrobial activity of the chloroform extract of Pergularia daemia Forsk Leaves. Advances in Pharmacology and Toxicology. 10; 2009:13–6.
- Athanasiadou S, Kyriazakis I, Jackson F and Coop RL. Direct anthelmintic effects of condensed tannins towards different gastrointestinal nematodes of sheep: in vitro and in vivo studies. Veterinary Parasitology. 99; 2001: 205-219
- Kishor KV, Satheesh KP and Venkatachalam T. Investigation of anthelmintic activity of Pergularia daemia leaves. Pharmacophore. 5(1); 2014: 44-48.
- Singh R., Mehta A, Mehta P. and Shukla, K. Anthelmintic activity of rhizome extracts of Curcuma longa and Zingiber officinale (Zingiberaceae). International Journal of Pharmacy and Pharmaceutical Sciences. 3(2); 2011: 236-237.
- Lakshmi SP and Bindu RN. A comparative study of the anthelmintic potential of Cleome viscosa L. and Cleome burmanni W. and A. Indian Journal of Pharmaceutical Sciences. 73(1); 2011: 98–100.
- Wang GX, Han J, Zao LW, Jiang DX, Liu YT and Liu XL. Anthelmintic activity of steroidal saponins from Paris polyphylla. Phytomedicine. 17(14); 2010: 1102-1105.
- Rajeshwar Y and Lalitha R. Preliminary phytochemical screening and in vitro anthelmintic effects of Acmella paniculata plant extracts. Biolife, 1(3); (2013):106-112.
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