Research Journal of Pharmacy and Technology

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Application of Dipterocarpus alatus Oil for Permeation Enhancement of Some Compounds


Affiliations
1 Division of Pharmaceutical Chemistry, Khon Kaen University, Khon Kaen, 40002, Thailand
2 Khon Kaen University, Khon Kaen, 40002, Thailand
3 Division of Pharmaceutical Technology, Khon Kaen University, Khon Kaen, 40002, Thailand
     

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The absorption of some drugs through skin is minimized due to the barrier of stratum corneum layerTherefore, searching for the new penetration enhancer from some chemical and natural compounds was widely investigatedNatural oil from Dipterocarpus alatus is very high production and supply in many parts of Thailand and is one of the potential natural oil which might be use for drug formulationThus, the aim of this study was to investigate the penetration enhancement of this natural oil to improve the permeation ability of some drugsKetoconazole, caffeine and ibuprofen were the model of drug use in this studySide by side diffusion testing was used for the study of the permeation enhancement of D.alatus oil and the amount of drug permeate was determined by UV-Visible spectrophotometerThe results were shown that D.alatus oil might be used as a permeation enhancer of some model drugs and could be applied to use as the excipient in drug formulation.

Keywords

Dipterocarpus alatus, Permeation Enhancement, Caffeine, Ketoconazole, Ibuprofen.
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  • Patil UK and Saraogi R. Natural products as potential drug permeation enhancer in transdermal drug delivery system. Archives in Dermatological Research. 306; 2014: 419-426.

  • Chen Y, Quan P, Liu X, Wang M, Fang LNovel Chemical Permeation Enhancer for Transdermal Drug Delivery. Asian Journal of Pharmaceutical Sciences. 9; 2014 : 51 54

  • Naik A, Kalia YN. and Guy RHTransdermal drug delivery: overcoming the skin’s barrier function. Pharmaceutical science & technology today. 3(9); 2000: 318 326

  • Vaddi HK, Wang LZ, Ho PC, Chan SY. Effect of some enhancers on the permeation of haloperidol through rat skin in vitro. International Journal of Pharmaceutics. 212; 2001: 247-235.

  • Vaddi HK, Ho PC and Chan SY. Terpenes in propylene glycol as skin permeation enhancers: permeation and partition of haloperidol, fourier transform infrared spectroscopy and differential scanning calorimetry. Journal of Pharmaceutical Sciences. 91; 2002: 1639-1651.

  • Aqil M, Ahad A, Sultana Y and Ali A. Status of terpenes as skin penetration enhancers. Drug Discovery Today. 12; 2007: 1061-1067.

  • Vashisth I, Ahad A, Aquil M and Agarwal SP. Investigation the potential of essential oils as penetration enhancer for transdermal losartan delivery: effectiveness and mechanism of action. Asian Journal of Pharmaceutical Sciences. 9; 2014: 260-267.

  • William AC and Barry BW. Essential oils as novel human skin penetration enhancers. International Journal of Pharmaceutics. 57; 1989: R7-R9.

  • Cornwell PA, Barry BW, Bouwstra JA, Gooris GS. Modes of action of terpene penetration enhancers in human skin; Differential scanning calorimetry, small-angle X-ray diffraction and enhancer uptake studies. International Journal of Pharmaceutics. 127; 1996: 9-26.

  • Cornwell PA and Barry BW. Sesquiterpene components of volatile oils as skin penetration enhancers for the hydrophilic permeant 5-fluorouracil. Journal of Pharmacy and Pharmacology. 46; 1994: 261-269.

  • Jain AK, Thomas NS, Panchagnula R. Transdermal drug delivery of imipramine hydrochloride: I. Effect of terpenes. Journal of Controlled Release. 79; 2002: 93-101.

  • Aggarwal G, Dhawan S and Hari KSF. Natural oils as skin permeation enhancers for transdermal delivery of olanzapine: in vitro and in vivo evaluation. Current Drug Delivery. 9; 2012: 172-181.


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  • Application of Dipterocarpus alatus Oil for Permeation Enhancement of Some Compounds

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Authors

Supawadee Daodee
Division of Pharmaceutical Chemistry, Khon Kaen University, Khon Kaen, 40002, Thailand
Tanakorn Punya
Khon Kaen University, Khon Kaen, 40002, Thailand
Narin Chansri
Division of Pharmaceutical Technology, Khon Kaen University, Khon Kaen, 40002, Thailand

Abstract


The absorption of some drugs through skin is minimized due to the barrier of stratum corneum layerTherefore, searching for the new penetration enhancer from some chemical and natural compounds was widely investigatedNatural oil from Dipterocarpus alatus is very high production and supply in many parts of Thailand and is one of the potential natural oil which might be use for drug formulationThus, the aim of this study was to investigate the penetration enhancement of this natural oil to improve the permeation ability of some drugsKetoconazole, caffeine and ibuprofen were the model of drug use in this studySide by side diffusion testing was used for the study of the permeation enhancement of D.alatus oil and the amount of drug permeate was determined by UV-Visible spectrophotometerThe results were shown that D.alatus oil might be used as a permeation enhancer of some model drugs and could be applied to use as the excipient in drug formulation.

Keywords


Dipterocarpus alatus, Permeation Enhancement, Caffeine, Ketoconazole, Ibuprofen.

References