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Synthesis, Characterization of New1,3,4-Thiadiazole Derivatives with Studying their Biological Activity


Affiliations
1 Department of Chemistry, Collage of Science for women, Baghdad University, Iraq
     

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In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1,3,4-thiadiazole) as base. The main hetrocyclic compounds (1,3,4-thiadiazole, oxazole) etc. 2-amino-5-mercapto-1,3,4-thiadiazole compound [1] was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and carbon disulfide. Oxidation of [1] via hydrogen peroxide, to have [2] which was treat with chloro acetyl chloride to get [3]. Preparation of oxazole ring [4] obtained from reacting of [3] with urea. Schiff bases [5 – 7] prepared by reacting [3] with different benzyl aldehyde. And Preparation of derivative [8 – 11], from reaction [3] with of hydrazine derivatives. Full characterization of the synthesized compounds was done by using of spectroscopic analysis such as FT-IR, 1H-NMR and C.H.N.S,

Keywords

1, 3, 4-Thiadiazole, Oxazole, Thiosemicarbazide, Schiff Bases.
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  • Synthesis, Characterization of New1,3,4-Thiadiazole Derivatives with Studying their Biological Activity

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Authors

Shetha F. Al-Zubiady
Department of Chemistry, Collage of Science for women, Baghdad University, Iraq
Zainab H. Kadhim Al-Khafaji
Department of Chemistry, Collage of Science for women, Baghdad University, Iraq
Iman M. Mohamed
Department of Chemistry, Collage of Science for women, Baghdad University, Iraq

Abstract


In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1,3,4-thiadiazole) as base. The main hetrocyclic compounds (1,3,4-thiadiazole, oxazole) etc. 2-amino-5-mercapto-1,3,4-thiadiazole compound [1] was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and carbon disulfide. Oxidation of [1] via hydrogen peroxide, to have [2] which was treat with chloro acetyl chloride to get [3]. Preparation of oxazole ring [4] obtained from reacting of [3] with urea. Schiff bases [5 – 7] prepared by reacting [3] with different benzyl aldehyde. And Preparation of derivative [8 – 11], from reaction [3] with of hydrazine derivatives. Full characterization of the synthesized compounds was done by using of spectroscopic analysis such as FT-IR, 1H-NMR and C.H.N.S,

Keywords


1, 3, 4-Thiadiazole, Oxazole, Thiosemicarbazide, Schiff Bases.

References