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Assessment of CD-147 Level in Women with Coronary Heart Disease after Menopause


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1 Biology Department, University of Kufa, Iraq
     

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In the current study, Seventy menopausal women have CHD were admitted to the Coronary Care Unit of AL-Sadder Teaching Hospital in AL-najaf AL-Ashraf during the period from January to April/2016 for the ages were ranging from 40 to 69 years old. The samples were divided into three groups (SA 25, UA 22, AMI 23), while the healthy group was composed of 20.The current study indicated a significant increase(p<0.05) in serum CD147 of CHD compared with healthy group, while a significant decrease (P<0.05)in serum E2 concentration of CHD compared with healthy group. The results also revealed a significant increase (p>0.05)of serum CD147concentration in AMI group as compare with UA group and SA group of CHD, While serum of E2 concentration showed a significantly decrease (p<0.05)in AMI compare with UA and SA groups of CHD. The result showed also a negative correlation between E2 and CD147.

Keywords

Coronary Heart Disease, Menopause, Estradiol and CD147.
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  • Cheek, D. (2003). What's the difference about heart disease in women?. Nursing, 33(8):36-42.

  • Vishal, R.T.; Annil, M.; Sudhaa, S. and Anil, S. (2010). Prevalence of cardiovascular risk factors in postmenopausal women: A rural study. Journal of Mid-life Health, 1:1, 26-29.

  • Hammod H.J.; Arshad Noori Al-Dujaili2 A.N. and Mohammed Noori Al-Dujaili, M.N.)2016). The Correlation between Cardiovascular Diseases in Obese Men with The Inflammatory Markers: Dyslipidemia, C-Reactive Protein and Tumor Necrosis Factor-α. RJPBCS., 7(3) pp. 809-814

  • Al-Dujaili, A.N; Adhraa Baqir Hassan, A.B. and Mahdi, N.S, (2016). Assessment of Vaspin And Risk Factors In Relation With Diabetic Mellitus Type II. RASĀYAN. J. Chem., 9(4): 566 - 572

  • Al-Kraity, W.R.H. and Arshad Noori Ghani Al-Dujaili, A.N.G, (2016). Assessment of Thrombospondin-1 Level in Type II Diabetic Patients. RJPBCS., 7(6) PP. 1201 -1210.

  • Santos, R.L.; Abreu, G.R.; Bissoli, N.S and Moyses, M.R. (2004). Endothelial mediators of 17beta-estradiol-induced coronary vasodilation in the isolated rat heart. BrazilianJournal of Medical and Biological Research, Vol.37, No. 4, pp. 569–575.

  • Arnal, J.F.; Fontaine, C.; Billon-Galés, A.; Favre, J.; Laurell, H.; Lenfant, F. and Gourdy, P.(2010). Estrogen receptors and endothelium. Arteriosclerosis, Thrombosis, andVascular Biology, Vol. 30, No. 8, pp. 1506-1512.

  • Chakrabarti, S.; Lekontseva, O. and Davidge. S.T. (2008). Estrogen is a Modulator of Vascular Inflammation. IUBMB Life, 60(6): 376–382.

  • Drevenšek, G. (2012). The Role of Sex Hormones in the Cardiovascular System, Sex Hormones, Prof.Raghvendra Dubey (Ed.), ISBN: 978-953-307-856-4.

  • Schmidt, R.; Bültmann, A.; Ungerer, M.; Joghetaei, N. and et al. (2006). Extracellular Matrix Metalloproteinase Inducer Regulates Matrix Metalloproteinase Activity in Cardiovascular Cells Implications in Acute Myocardial Infarction. Circulation, 113:834-841.

  • Rong, M-Y.; Wang, C-H.; Wu, Z-B.; Zeng, W.; Zhao-hui Zheng, Z-H; Han, Q. and et al. (2014). Platelets induce a proinflammatory phenotype in monocytes via the CD147 pathway in rheumatoid arthritis. Arthritis Research & Therapy, 16:478.pp1-10.

  • Yurchenko, V.; Zybarth, G.O.; Connor, M.; Dai, W.W.; Franchin, G.; Hao, T. and et al. (2002). Active site residues of cyclophilin-A are crucial for its signaling activity via CD147. J. Biol. Chem., 277:22959–22965.

  • Song, F.; Zhang, X.; Ren, X.B.; Zhu. P.; Xu, J.; Wang, L. and et al. (2011). CyclophilinA(CYP-A) induces chemotaxis independent of its peptidylprolyl cis-trans isomerase activity: direct binding between CYP-A and the ectodomain of CD147. J. Biol. Chem., 286:8197–8203.

  • Al-Rawi, K.(2000). Entrance to the Statistics. Second edition. Faculty of Agriculture and Forestry, University of Mosul.

  • Domenico, D.; Marco, G.; Michele, M.; Francesco, P.; Modena, A.B.; Bolis, P.F. and et al. (1999).The effect of menopause on blood lipid and lipoprotein levels. Atherosclerosis, 147:147-53.

  • Chang, C-J; Wu1, C-H; Yao, W-J; Yang, Y-C; Wu, J-S and Lu, F-H. (2000). Relationships of age, menopause and central obesity on cardiovascular disease risk factors in Chinese women. International Journal of Obesity , 24, 1699-1704.

  • Hammod H.J.; Arshad Noori Al-Dujaili2 A.N. and Mohammed Noori Al-Dujaili, M.N. )2016). Relationship Between Adipocyte Fatty Acid–Binding Protein In Obese Men With Cardiovascular Diseases. RJPBCS., 7(3) pp. 804-808.

  • Al-Dujaili, A.N.G and Hadeel Haider Salih Al-Dujaili, H.H.S.(2016). Assessment of Osteocalcin Level in Association with Type 2 Diabetic Patients. RJPBCS.,7(6).

  • James, R.S. (1998). diabetes mellitus and cardiovascular disease in women. Arch. Intern.Med., 158:617-621.

  • Camici, P.G. and Crea, F. (2007). Coronary microvascular dysfunction. N. Engl. J. Med., 356:830–840.

  • Falk, E.; Shah, P.K. and Fuster, V. (1995). Coronary plaque disruption. Circulation, 92:657–671.

  • Kusnoor, A.V.; Ferguson, A.D. and Falik, R. (2011). Ischemic Heart Disease in Women :A Review for Primary Care Physicians South Med. J.,104(3):200-204.

  • Seizer, P.; Ochmann, C.; Schonberger, T. and et al. (2011). Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion. Arterioscler. Throm. Vasc. Biol., 31:1377–1386.

  • Schmidt, R.; Bultmann, A.; Fischel, S.; Gillitzer, A.; Cullen, P.; Walch, A.; Jost, P.; Ungerer, M.; Tolley, N.D.; Lindemann, S. and et al. (2008). Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB dependent inflammation in monocytes. Circ. Res., 102: 302–309.

  • Yurchenko, V.; Constant S. and Bukrinsky, M. (2005). Dealing with the family: CD147 interactions with cyclophilins. Immunology, 117: 301–309.

  • Zeng, B.; Prasan, A.; Fung, K.C.; Solanki, V.; Bruce, D.; Freedman, S.B. and Brieger, D. (2005). Elevated circulating levels of matrix metalloproteinase-9 and -2 in patients with symptomatic coronary artery disease. Intern. Med. J., 35: 331–5.

  • Seizer, P.; Borst, O.; Langer, H.F.; Bultmann, A.; Munch, G.; Herouy, Y. and et al. (2009). EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI– EMMPRIN interaction. Thromb. Haemost., 101: 682–6.

  • Virmani, R.; Kolodgie, F.D.; Burke, A.P.; Farb, A; Schwartz, S.M. (2000). Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol., 20:1262–1275.

  • Libby, P. (2002). Current concepts of the pathogenesis of acute coronary syndromes. Circulation, 104:365–372.

  • Kai, H.; Ikeda, H.; Yasukawa, H.; Kai, M.; Seki, Y.; Kuwahara, F.; Ueno, T.; Sugi, K. and Imaizumi, T. (1998). Peripheral blood levels of matrix metalloproteases-2 and -9 are elevated in patients with acute coronary syndromes. J .Am. Coll. Cardiol., 32:368 –372

  • Seizer, P.; Gawaz, M. and May A.E. (2014). Cyclophilin A and EMMPRIN (CD147) in cardiovascular diseases. Cardiovascular Research, 102, 17–23.


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  • Assessment of CD-147 Level in Women with Coronary Heart Disease after Menopause

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Authors

Arshad Noori Ghani Al-Dujaili
Biology Department, University of Kufa, Iraq
Wijdan Rajh Hamza Al-Kraity
Biology Department, University of Kufa, Iraq

Abstract


In the current study, Seventy menopausal women have CHD were admitted to the Coronary Care Unit of AL-Sadder Teaching Hospital in AL-najaf AL-Ashraf during the period from January to April/2016 for the ages were ranging from 40 to 69 years old. The samples were divided into three groups (SA 25, UA 22, AMI 23), while the healthy group was composed of 20.The current study indicated a significant increase(p<0.05) in serum CD147 of CHD compared with healthy group, while a significant decrease (P<0.05)in serum E2 concentration of CHD compared with healthy group. The results also revealed a significant increase (p>0.05)of serum CD147concentration in AMI group as compare with UA group and SA group of CHD, While serum of E2 concentration showed a significantly decrease (p<0.05)in AMI compare with UA and SA groups of CHD. The result showed also a negative correlation between E2 and CD147.

Keywords


Coronary Heart Disease, Menopause, Estradiol and CD147.

References