Research Journal of Pharmacy and Technology

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A Review on Spherical Crystallization Mechanisms and Characterization


Affiliations
1 Department of Chemical Engineering and Technology, University College of Technology, Osmania University, Hyderabad, Telangana, India
     

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Spherical crystallization is a novel agglomeration technique that can transform crystals directly into a spherical form during the crystallization process itself. In the spherical crystallization process, crystal formation, growth and agglomeration occur simultaneously within the same system. In this method, a third solvent called the bridging liquid is added in a smaller amount to purposely induce and promote the formation of agglomerates. Spherical agglomerates can be manufactured by four techniques, namely, spherical agglomeration, quasi emulsion solvent diffusion, ammonia diffusion and neutralization method. Spherical crystallization is influenced by solvent system, solubility, feeding rate, agitation, residence time, temperature and initial size of the crystals formed. Characterization includes mainly particle size distribution, morphology, porosity and mechanical properties such as compressibility, tensile strength, mechanical strength and elasticity. The spherical agglomerates prepared using spherical agglomeration possesses good physico-mechanical properties like spherical shape, mechanical strength, compressibility and low elastic recovery.

Keywords

Spherical Crystallization, Benzoic Acid, Spherical Agglomerates, Mechanical Properties.
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  • Bausch A, Leuenberger H. Wet spherical agglomeration of proteins as a new method to prepare parenteral fast soluble dosage forms. Int. J. Pharm. 1994; 101, 63-70.

  • Blandin AF, Mangin D, Rivoire A, Klein JP, Bossoutrot JM. Agglomeration in suspension of salicylic acid fine particles: influence of some process parameters on kinetics and agglomerate final size. Powder Technol. 2003; 130, 316-323.

  • Blandin AF, Mangin D, Rivoire A, Klein JP, Bossoutrot JM. Modeling of agglomeration in suspension: Application to salicylic acid microparticles. Powder Technol. 2005; 156, 19-33.

  • Bos AS, Zuiderweg FJ, Size of agglomerates in batch wise suspension agglomeration. Chem. Eng.Res.Des. 1987; 65, 187.

  • Capes CE, Sutherland JP. Formation of spheres from finely divided solids in liquid suspension. I&EC Proceed Des. Dev. 1967; 6, 146-154.

  • Chow AHL, Leung MWM. A study of the mechanisms of wet spherical agglomeration of pharmaceutical powders. Drug Dev Ind Pharma. 1996; 4, 357-371.

  • Espitalier F, Biscans B, Laguerie C, Authelin JR, Deleuil M. Crystallization of an active substance from emulsion droplets. Interactions between usage properties and process. Industrial Crystallization. 1993; 1(9):3-025-3-30.

  • Ettabia A. Preparation of a pure paracetamol for direct compression by spherical agglomeration. Pharmazeutische Industrie. 1997; 7(59), 625-631.

  • Farnand JR, Smith HM, Puddington IE. Spherical agglomeration of solids in liquid suspension. Can. J. Chem. Eng. 1961; 39, 94-7.

  • Goczo H, Szabo-Revesz P, Farkas B, Hasznos-Nezdei M, Serwanis SF, Pintye-Hodi AK, et al. Development of spherical crystals of acetylsalicylic acid for direct tablet-making. Chem. Pharm. Bull. 2000; 48, 1877-81.

  • Gohel MC, Parikh RK, Shah H, Dubey RR. Improvement in flowability and compressibility of ampicillin trihydrate by spherical crystallization. Ind. J. Pharm Sci. 2003; 65, 634-637.

  • Gonzalez DA, Biscans B. Spherical agglomeration during crystallization of an active pharmaceutical ingredient. Powder Technol. 2002; 128, 188-194.

  • Kachrimanis K, Ktistis G, Malamataris S. Crystallization conditions and physicomechanical properties of ibuprofen- Eudragit S100 spherical crystal agglomerates prepared by the solvent-change technique. Int. J. Pharm. 1998; 173, 61-74.

  • Kawashima Y, Capes CE. Experimental study of the kinetics of spherical agglomeration in as stirred vessel. Powder Technol. 1974; 10, 85-92.

  • Kawashima Y, Capes CE. Further studies of the kinetics of spherical agglomeration in a stirred vessel. Powder Technol. 1976; 13, 279-288.

  • Kawashima Y, Cui F, Takeuchi H, Niwa T, Hino T, Kiuchi K. Improvements in flowability and compressibility of pharmaceutical crystals for direct tabletting by spherical crystallization with a 2 solvent system. Powder Technol. 1994; 78, 151-157.

  • Kawashima Y, Cui F, Takeuchi H, Niwa T, Hino T, Kiuchi K. Improved static compression behaviors and tablettabilities of spherically agglomerated crystals produced by the spherical crystallization technique with a two-solvent system. Pharma. Res. 1995; 12, 1040-4.

  • Kawashima Y, Cui F, Takeuchi H, Niwa T, Hino T, Kiuchi K. Parameters determining the agglomeration behavior and the micromeritic properties of spherically agglomerated crystals prepared by the spherical crystallization technique with miscible solvent systems. Int. J. Pharm. 1995; 119, 139-47.

  • Kawashima Y, Furukawa K, Takenaka H. The physicochemical parameters determining the size of agglomerate prepared by the wet spherical agglomeration technique. Powder Technol. 1981; 30, 211-16.

  • Kawashima Y, Imai M, Takeuchi H, Yamamoto H, Kamiya K, Hino T. Improved flowability and compactibility of spherically agglomerated crystals of ascorbic acid for direct tabletting designed by spherical crystallization process. Powder Technol. 2003; 130, 283-289.

  • Kawashima Y, Imai M, Takeuchi H, Yamamoto H, and Kamiya, K, Development of Agglomerated Crystals of Ascorbic acid by the Spherical Crystallization Technique for Direct Tabletting, and Evaluation of their Compactibilities, Kona. 2002; 20, 251-261.

  • Kawashima Y, Lin SY, Ogawa M, Handa T, Takenaka H. Preparations of agglomerated crystals of polymorphic mixtures and a new complex of indomethacin-epirizole by the spherical crystallization technique. J. Pharm. Sci. 1985; 74, 1152-6.

  • Kawashima Y, Naito M, Lin SY, Takenaka H. An experimental study of the kinetics of the spherical crystallization of sodium theophylline monohydrate. Powder Technol. 1983; 34, 255-60.

  • Kawashima Y, Okumura M, Takenaka H. Spherical crystallization: direct spherical agglomeration of salicylic acid crystals during crystallization. Science. 1982; 4550(216), 1127-8.

  • Kawashima Y, Okumura M, Takenaka H. The effects of temperature on the spherical crystallization of salicylic acid. Powder Technol. 1984; 39, 41-47.

  • Kawashima Y, Takeuchi H, Niwa T, Hino T, Yamakoshi M, Kihara K. Preparation of spherically agglomerated crystals of an antibacterial drug for direct tabletting by a novel spherical crystallization technique. Congr. Int. Technol. Pharm. 1989; 5, 228-34.

  • Kazuhiko I, Kawashima Y, Takeuchi H, Yamamoto H, Isshiki N, Momose D. Primary crystal growth during spherical agglomeration in liquid: designing an ideal dry powder inhalation system. Powder Technol. 2002; 126, 266-274.

  • Kumar S, Chawla G, Bansal AK. Spherical crystallization of mebendazole to improve processability. Pharm. Dev. Technol. 2008; 13, 559-568.

  • Lasagabaster A, Martin C, Goni MM. Preparation of spherically agglomerated crystals of the 3,5-diglucoside of cyaniding (cyanin). J. Chem. Tech. Biotechnol. 1994; 60, 397-403.

  • Machiya K, Koga K, Mukuta T, Moriki S, Kagara K, Ooshima H. Production of Spherical Agglomerates of Cephalosporin Antibiotic Crystal. J. Chem. Eng. Japan. 2008; 41, 1017-1023.

  • Martino PD, Barthelemy C, Piva F, Joiris E, Palmieri GF, Martelli S. Improved dissolution behavior of fenbufen by spherical crystallization. Drug Dev Ind Pharm. 1999; 25, 1073-1081.

  • Morishima K, Kawashima Y, Kawashima H, Takeuchi H, Niwa T, Hino T. Micromeritic characteristics and agglomeration mechanisms in the spherical crystallization of bucillamine by the spherical agglomeration and the emulsion solvent diffusion methods. Powder Technol. 1993; 76, 57-64.

  • Morishima K, Kawashima Y, Kawashima H, Takeuchi H, Niwa T, Hino T. Tabletting properties of bucillamine agglomerates prepared by the spherical crystallization technique. Int. J. Phar. 1994; 105, 11-18.

  • Muller M, Loffler F. Development of agglomerate size and structure during spherical agglomeration suspension. Part. Part. Syst. Charact. 1996; 13, 322-326.

  • Nayak U A, Mutalik S, Meka S R, Averineni R K, Pralhad K, Nayanabhirama U. Preparation and, in vitro, preclinical and clinical studies of aceclofenac spehrical agglomerates. Eur. J. Pharm. Sci. 2008; 70, 674-683.

  • Niwa T, Takeuchi H, Hino T, Itoh A, Kawashima Y, Kiuchi K. Preparation of agglomerated crystals for direct tabletting and microencapsulation by the spherical crystallization technique with a continuous system. Pharm. Res. 1994; 11, 478-484.

  • Nokhodchi A, Maghsoodi Z, Davood H, Mohammad J. Preparation of agglomerated crystals for improving flowability and compactability of poorly flowable and compactible drugs and excipients. Powder Technol. 2007; 175, 73-81.

  • Podczeck F, Jones B, (2004), Pharmaceutical capsules 2nd edition.

  • Puechagut HG, Bianchotti J, Chiale CA. Preparation of norfloxacin spherical agglomerates using the ammonia diffusion system. J. Pharm. Sci. 1998; 87, 519-23.

  • Re M, Biscans B. Preparation of miscrospheres of ketoprofen with acrylic polymers by a quasi-emulsion solvent diffusion method. Powder Technol. 1999; 101, 120-133.

  • Revesz PS, Nezdei MH, Farkas B, H G, Hodi K, P, Eros I. Crystal growth of drug materials by spherical crystallization. J. Cryst. Growth. 2002; 237-239, 2240-2245.

  • Ribardiere TP, Couarraze G, Puisieux F. Modification of ketoprofen bead structure produced by the spherical crystallization technique with a two-solvent system. Int. J. Pharm. 1996; 144, 195-207.

  • Sadowski Z. Selective spherical agglomeration of fine salt type mineral particles in aqueous solution. Colloids Surfaces A: Physicochem. Eng. Aspects. 1995; 96, 277-285.

  • Sano A, Kuriki T, Kawashima Y, Takeuchi H, Hino T, Niwa T. Particle design of tolbutamide by the spherical crystallization technique. III. Micromeritic properties and dissolution rate of tolbutamide spherical agglomerates prepared by the quasi-emulsion solvent diffusion method and the solvent change method. Chem. Pharm. Bull. 1990; 38, 733-739.

  • Sano A, Kuriki T, Kawashima Y, Takeuchi H, Hino T, Niwa T. Particle design of tolbutamide by spherical crystallization technique. V. Improvement of dissolution and bioavailability of direct compressed tablets prepared using tolbutamide agglomerated crystals. Chem. Pharm. Bull. 1992; 40, 3030-3035.

  • Sirianni AF, Capes CE, Puddington IE. Recent experience with the spherical agglomeration process. Can. J. Chem. Eng. 1969; 47, 166-170.

  • Subero CC, Mangin D, Rivoire A, Blandin AF, Klein JP. Agglomeration in suspension of salicylic acid fine particles: Analysis of the wetting period and effect of the binder injection mode on the final agglomerate size. Powder Technol. 2006; 161, 98-109.

  • Sutherland JP. The agglomeration of aqueous suspensions of graphite. Can. J. Chem. Eng. 1962; 40, 268-272.

  • Tambo N, Watanabe Y. Physical aspect of flocculation process. I. Fundamental treatise. Water Res. 1979; 13, 429-39.

  • Ueda M, Nakamura Y, Makita H, Imasato Y, Kawashima Y. Particle design of enoxacin by spherical crystallization technique. I. Principle of ammonia diffusion system (ADS). Chem. Pharm. Bull. 1990; 38, 2537-41.

  • Ueda M, Nakamura Y, Makita H, Imasato Y, Kawashima Y. Particle design of enoxacin by spherical crystallization technique. II. Characteristics of agglomerated crystals. Chem. Pharm. Bull. 1991; 39, 1277-1281


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  • A Review on Spherical Crystallization Mechanisms and Characterization

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Authors

Jyothi Thati
Department of Chemical Engineering and Technology, University College of Technology, Osmania University, Hyderabad, Telangana, India
Sailu Chinta
Department of Chemical Engineering and Technology, University College of Technology, Osmania University, Hyderabad, Telangana, India

Abstract


Spherical crystallization is a novel agglomeration technique that can transform crystals directly into a spherical form during the crystallization process itself. In the spherical crystallization process, crystal formation, growth and agglomeration occur simultaneously within the same system. In this method, a third solvent called the bridging liquid is added in a smaller amount to purposely induce and promote the formation of agglomerates. Spherical agglomerates can be manufactured by four techniques, namely, spherical agglomeration, quasi emulsion solvent diffusion, ammonia diffusion and neutralization method. Spherical crystallization is influenced by solvent system, solubility, feeding rate, agitation, residence time, temperature and initial size of the crystals formed. Characterization includes mainly particle size distribution, morphology, porosity and mechanical properties such as compressibility, tensile strength, mechanical strength and elasticity. The spherical agglomerates prepared using spherical agglomeration possesses good physico-mechanical properties like spherical shape, mechanical strength, compressibility and low elastic recovery.

Keywords


Spherical Crystallization, Benzoic Acid, Spherical Agglomerates, Mechanical Properties.

References